Sökning: "Transport Modelling"

Visar resultat 6 - 10 av 490 avhandlingar innehållade orden Transport Modelling.

1. 6. Modelling and Simulating Demand-Responsive Transport

   Författare :Sergei Dytckov; Jan A. Persson; Paul Davidsson; Erik Jenelius; Malmö universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; On-Demand Mobility; Demand Responsive Transport; Modelling and Simulation; Sustainability;

   Sammanfattning : Public transport is an efficient way to transport large volumes of travellers. However, there are systemic issues that make it hard for conventional public transport to provide efficient service on finer levels, like first- and last-mile problems or low-demand areas. LÄS MER

3. 7. Congestion Charging in Urban Networks : Modelling Issues and Simulated Effects

   Författare :Ida Kristoffersson; Leonid Engelson; Otto Anker Nielsen; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Transport Modelling; Congestion Charging; Departure Time Choice; Dynamic Traffic Simulation; Welfare Effects; Equity;

   Sammanfattning : One of the major challenges cities face today, in their development towards sustainable urban areas, is the need for an efficient and environmentally friendly transport system. This transport system should manage to tie together the city without strong adverse impact on urban environment, air-quality and climate change. LÄS MER

4. 8. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

   Författare :Erik Sjögren; Hans Lennernäs; Scott Obach; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

   Sammanfattning : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. LÄS MER

5. 9. Blood-Brain Barrier Transport : Investigation of Active Efflux using Positron Emission Tomography and Modelling Studies

   Författare :Stina Syvänen; Margareta Hammarlund-Udenaes; Mats Bergström; Gunnar Blomquist; Jashvant Unadkat; Uppsala universitet; []
   Nyckelord :Pharmaceutical biosciences; pharmacokinetics; P-glycoprotein; blood-brain barrier; modelling; PET; active efflux; species differences; [11C]verapamil; drug development; Farmaceutisk biovetenskap;

   Sammanfattning : This thesis examines the transport of exogenous molecules across the blood-brain barrier (BBB), focusing on active efflux, using positron emission tomography (PET), computer simulation and modelling. P-glycoprotein (P-gp) inhibition was studied using [11C]verapamil and [11C]hydroxyurea was investigated as a new marker for active efflux transport. LÄS MER

7. 10. Monitoring transport and fate of de-icing salt in the roadside environment : Modelling and field measurements

   Författare :Annika Lundmark; Per-Erik Jansson; Bo Olofsson; Ann-Catrine Norrström; Helen K. French; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chloride; De-icing salt; Groundwater; Modelling; Monitoring; Road; Roadside; Soil water; Water in nature and society; Vatten i natur och samhälle;

   Sammanfattning : Roads and traffic are a major non-point source of pollutants and may have severe impacts on surface water, groundwater, soil and vegetation. In cold climates, de-icing salt is one such pollutant that may cause increased chloride concentrations and induce other effects on the environment. LÄS MER