Sökning: "Cx43"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Cx43.
1. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
Sammanfattning : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. LÄS MER
2. Connexin43 in astroglial gap junctions. Regulation by age, neurotransmitters, GH and IGF-I
Sammanfattning : Connexins form gap junctions that are aqueous pores allowing low-molecular (.... LÄS MER
3. Epigenetic mechanisms and regulatory aspects of human cancer and neural progenitor cells : implications for diagnosis and therapy
Sammanfattning : Epigenetic is defined as heritable modification or properties of the functional genome that are not directly embedded in the DNA sequence. Epigenetic changes include DNA methylation, histone modifications and RNA-mediated gene silencing. LÄS MER
4. Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase
Sammanfattning : Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains very poor, despite advances in management. LÄS MER
5. On CNS injury and olfactory ensheathing cell engraftment strategies
Sammanfattning : The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited because of lack of nerve-growth stimulatory factors and presence of an insurmountable molecular environment for injured axons. This thesis aims to study neural regeneration following adult CNS injury, using rodent models of spinal cord injury, dorsal root avulsion, and Parkinson s disease. LÄS MER