Sökning: "HSV-tk"

Hittade 3 avhandlingar innehållade ordet HSV-tk.

1. 1. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models

   Författare :Thomas Asklund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glioma; gap junction; Cx43; bystander effect; HSV-tk; HDAC inhibitor; tyrosine kinase inhibitor;

   Sammanfattning : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. LÄS MER

3. 2. Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase

   Författare :Zahidul Khan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Malignant glioma; suicide gene therapy; bystander effect; gap junction; neural stem cell; 4-phenylbutyrate; epigenetics; cell differentiation;

   Sammanfattning : Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains very poor, despite advances in management. LÄS MER

4. 3. Vector development for suicide gene therapy

   Författare :Alar Aints; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

   Sammanfattning : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. LÄS MER