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Visar resultat 1 - 5 av 61 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa

    Författare :Silvia Melgar; Nadine Cerf-Bensussan; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestinal mucosa; intraepithelial lymphocyte; lamina propria lymphocyte; γδ T cell; regulatory T cell; cytotoxicity; cytokine; basal lymphoid aggregate; ulcerative colitis; Crohn s disease;

    Sammanfattning : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. LÄS MER

  3. 2. On CD4+ T Lymphocytes in Solid Tumours

    Författare :Per Marits; Ola Winqvist; Magnus Thörn; Alex Karlsson-Parra; Uppsala universitet; []
    Nyckelord :Molecular medicine; Tumour immunology; T lymphocytes; sentinel node detection; colon cancer; urinary bladder cancer; adoptive immunotherapy; Molekylärmedicin;

    Sammanfattning : This thesis deals with recognition and elimination of tumours by T lymphocytes and their use in adoptive immunotherapy.The first tumour-draining lymph node; the sentinel node, is identified by peritumoural injection of a tracer. This is the hypothesised location for the activation of tumour-reactive lymphocytes. LÄS MER

  4. 3. Role of Toll-like receptors in airway inflammation

    Författare :Anne Månsson; Klinisk och experimentell allergiforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphocytes; peripheral blood; allergic rhinitis; tonsils; eosinophils; specific allergen immunotherapy;

    Sammanfattning : Toll-like receptors (TLRs) are germline-encoded pathogen-recognition receptors that detect different microbial structures and activate the immune system. The human TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. LÄS MER

  5. 4. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers

    Författare :Ida Lundberg; Richard Palmqvist; Maria Wikberg; Sofia Edin; Anita Sjölander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; BRAF; KRAS; SOX2; CDX2; cancer stem cell; Th1 lymphocytes; miRNA; prognosis;

    Sammanfattning : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. LÄS MER

  7. 5. T cell Function in Patients with Dilated Cardiomyopathy

    Författare :Erika Lindberg; Göteborgs universitet; []
    Nyckelord :cardiomyopathy; lymphocytes; cytokines; autoimmunity; infection;

    Sammanfattning : Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by dilatation of one or both ventricles together with decreased systolic function. Its etiology is still largely unknown. LÄS MER