Sökning: "Target levels"

Visar resultat 31 - 35 av 1142 avhandlingar innehållade orden Target levels.

  1. 31. Triggering and inhibitory molecules affecting target cell recognition by NK cells

    Författare :Margarita Salcedo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cell; MHC class 1; NKinhibitory receptors; costimulatory molecules ISBN 9 1-628-2643-3;

    Sammanfattning : NK cells were described originally for their ability to lyse certain tumor cell lines without prior immunization. MHC class I molecules have been shown to deliver a negative signal to NK cells preventing killing of target cells. This reaction is mediated via specific receptors on NK cells, referred to as KIR in man and Ly49 in mouse. LÄS MER

  3. 32. Chemical proteomics for drug target deconvolution and to study biological systems

    Författare :Christian M Beusch; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mass spectrometry-based proteomics has become an irreplaceable method for the unbiased and system-wide study of protein chemistry. As modern proteomics methods can not only be applied to quantify protein expression levels, but also monitor changes in post-translational modifications, subcellular localization, turnover rate, and lastly protein structures, it has become a method of choice for drug discovery and dissecting cellular processes. LÄS MER

  4. 33. Neuroblastoma as a target for effector mechanisms of the immune system

    Författare :Anna De Geer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma (NB) is the most common solid extracranial tumor in children. Despite intensive multimodal treatment, the prognosis for high-risk NB patients remains poor and therefore new treatment modalities are needed. The main aim of my studies was to assess NB as a target for cytotoxic T lymphocyte (CTL)-mediated immunotherapy. LÄS MER

  5. 34. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease

    Författare :Lena Brånén; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; cell replication; Cardiovascular system; Kardiovaskulära systemet; spindle-shaped; epithelioid; smooth muscle cells; periadventitial cuff injury; sTNF-R1; bone marrow transplantation; chimeric fusion protein; atherogenic diet; ApoE; TNF-a; genetically altered mice; en face preparation; atherosclerosis; neointimal hyperplasia;

    Sammanfattning : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). LÄS MER

  7. 35. Energy metabolism as a target for new treatment strategies in Huntington’s disease

    Författare :Marie Sjögren; Biomarkörer vid hjärnsjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington´s disease; Energy metabolic alteration; Weight loss; Skeletal muscle; Adipose tissue; R6 2; Ghrelin; Liraglutide;

    Sammanfattning : Huntington´s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and motoric dysfunctions as well as psychiatric problems. Accumulating evidence, however, suggests altered energy metabolism and a hyper-catabolic state as key features of HD pathology. LÄS MER