Sökning: "antibody-dependent cell-mediated cytotoxicity"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden antibody-dependent cell-mediated cytotoxicity.

  1. 1. Triggering and mechanisms of natural killer cell mediated cytotoxicity

    Författare :Yenan Bryceson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Natural killer cells; antibody dependent cellular cytotoxicity; natural cytotoxicity; immunodeficiency; hemophagocytic lymphohistiocytosis;

    Sammanfattning : Natural killer (NK) cells are innate immune cells that contribute to defense against infected and transformed cells by target cell killing and cytokine release. In addition, data suggest that NK cells contribute to immune homeostasis and reproduction. LÄS MER

  3. 2. Molecular specificities of NK cell-mediated recognition of human tumor cells

    Författare :Mattias Carlsten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addressed the molecular specificity of NK cell-mediated recognition of freshly isolated human tumor cells. LÄS MER

  4. 3. Studies of immune mechanisms in myasthenia gravis

    Författare :Biying Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :myasthenia gravis; acetylcholine receptor; ß-adrenergic receptor; antibody; T cell receptor; antibody-dependent cell-mediated cytotoxicity; gene polymorphism;

    Sammanfattning : Myasthenia gravis (MG) has been considered the prototype of autoantibody-mediated autoimmune diseases. The pathogenic autoantibodies are directed against the acetylcholine receptor (AChR). Several mechanisms by which these antibodies (AChR Ab) disturb the function of the receptor have been elucidated. LÄS MER

  5. 4. In vitro studies of natural and tumor-associated immunity in patients with transitional cell carcinoma of the urinary bladder

    Författare :Marita Troye-Blomberg; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Peripheral blood lymphocytes (PBL) from patients with transitional cell carcinoma of the urinary bladder (TCC-bladder) were studied using a SlCr-release assay for their in vitro cytotoxicity against a panel of allogeneic tissue culture cell lines of TCC-bladder and other origins. Control PBL were obtained from four different groups of donors. LÄS MER

  7. 5. Mechanisms influencing natural killer cell recognition of tumour cells

    Författare :Monika Enqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK cells with increased functionality. The process leading to gain of function through inhibition is known as NK cell education. LÄS MER