Sökning: "atherothrombosis"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet atherothrombosis.

  1. 1. Microparticles in hemophilia : friend or foe? To improve hemostasis or to induce atherothrombosis?

    Författare :Yanan Zong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : As one of the most well-known inherited bleeding disorders, hemophilia A (HA) is caused by the deficiency or dysfunction of coagulation factor VIII (FVIII). Patients with HA (PWHA) suffer from abnormal bleeding after injuries or surgeries, or even spontaneous bleeding in severe cases, particularly at joints and muscles. LÄS MER

  3. 2. Effects of combined oral contraceptives on hemostasis and biochemical risk indicators for venous thromboembolism and atherothrombosis

    Författare :Marianne van Rooijen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Combined oral contraceptives; emergency contraception; menstrual cycle; ethinylestradiol; levonorgestrel; desogestrel; lipoproteins; hemostasis; risk indicators; APC resistance; SHBG;

    Sammanfattning : Combined oral contraceptives (COCs) are one of the most common contraceptive methods in the world. Already a few years after their introduction, in the early 1960s, case reports were published showing associations between use of COCs and venous and arterial thromboembolism. LÄS MER

  4. 3. Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease

    Författare :Anna Cederholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Systemic lupus erythematosus; cardiovascular disease; atherosclerosis; atherothrombosis; antiphospholipid antibodies; Annexin A5;

    Sammanfattning : Systemic Lupus Erythematosus (SLE) is a clinical syndrome of autoimmune origin. It manifests in diverse clinical and serological patterns and is considered to represent a prototype multisystemic autoimmune disease. The etiopathigenesis of SLE remains incompletely understood. LÄS MER

  5. 4. Fibrinogen and susceptibility to myocardial infarction : role of gene-gene and gene-environment interactions

    Författare :Maria Nastase Mannila; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherothrombosis; epistasis; fibrinogen; fibrinogen gamma; fibrin clot structure; haplotypes; myocardial infarction; pleiotropy; SNPs;

    Sammanfattning : Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in plasma at concentrations normally ranging between 2-4 g/L. The fibrinogen molecule consists of two sets of three non-identical polypeptide chains, which are encoded by the fibrinogen gamma (FGG), fibrinogen alpha (FGA) and fibrinogen beta (FGB) genes clustered on chromosome 4. LÄS MER

  7. 5. Tumor necrosis factor superfamily members CD137 and OX40 ligand in vascular inflammation

    Författare :Leif Söderström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis, an inflammatory disease, is the major cause of cardiovascular disease - the main cause of death worldwide. T cells are central orchestrators of inflammation in atherosclerosis and critically depend on costimulation for adequate function. LÄS MER