Sökning: "RNP"

Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet RNP.

  1. 1. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases

    Författare :Tanja Lövgren; Lars Rönnblom; Gunnar Alm; Maija-Leena Eloranta; Andrej Tarkowski; Uppsala universitet; []
    Nyckelord :Medicine; Systemic lupus erythematosus; Sjögren s syndrome; type I interferon; plasmacytoid dendritic cell; natural interferon-producing cell; immune complex; RNP; Ro SSA; La SSB; Medicin;

    Sammanfattning : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. LÄS MER

  3. 2. Transcription and transport of a messenger RNP particle : novel regulatory mechanisms

    Författare :Karin Kylberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In all living cells gene expression is a central process that involves several steps, including transcription, processing, transport and translation. A fine-tuning of these events is a pre-requisite for proper cellular function. LÄS MER

  4. 3. Assembly and transport of messenger and ribosomal RNP particles in the dipteran Chironomus tentans

    Författare :Teresa Soop; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene expression in eukaryotic organisms commences with the synthesis of a precursor RNA, which has to be extensively processed to yield a mature RNA molecule. In addition to processing, the RNA molecule needs to associate with a proper set of proteins. LÄS MER

  5. 4. Autoantibodies in healthy blood donors, rheumatic and autoimmune liver diseases

    Författare :Awais Ahmad; Christopher Sjöwall; Charlotte Dahle; Stergios Kechagias; Marco W.J. Schreuers; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Autoimmunity is a common phenomenon where the immune system recognises the body's own tissues. Autoimmunity can lead to disease if tissue damage occurs. Autoimmune diseases affect 5–10% of the global population and in many of these autoantibodies can be detected. The autoantibodies can be detected with several different methods. LÄS MER

  7. 5. Investigation of RNase P active site residues and catalytic domain interaction

    Författare :Guanzhong Mao; Leif Kirsebom; Roland Hartmann; Britt-marie Sjöberg; Anders Byström; Anthony Forster; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNase P; Ribozyme; PRORP; Induced fit model; RNase P-pre-tRNA interaction; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : RNase P is an essential endoribonuclease responsible for the maturation of the tRNA 5’end. The RNase P family encompasses the ribozyme based, RNase P RNP, and proteinaceous RNase P (PRORP). The ribozyme based RNase P is widely distributed in most species while PRORP has so far mainly been found in some eukaryotic cells. LÄS MER