Sökning: "SpeB"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet SpeB.

1. 1. Studies on secreted cysteine proteases of Streptococcus pyogenes : IdeS and SpeB

   Författare :Reine Vindebro; Ulrich von Pawel-Rammingen; Wolfgang Knecht; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Streptococcus pyogenes; Group A Streptococci; GAS; virulence factor; IdeS; SpeB; cysteine protease; protease inhibitor; IgG; immune evasion; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

   Sammanfattning : The pathogen Streptococcus pyogenes is a significant cause of human morbidity and mortality. Most of the work in this thesis is focused on streptococcal virulence factor IdeS, but the thesis also features work on SpeB, another streptococcal virulence factor. LÄS MER

3. 2. Pathogen-host interactions at the surface of Streptococcus pyogenes

   Författare :Patrik Nyberg; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; C3a; LL-37; antimicrobial peptide; GRAB; alpha-2-macroglobulin; proteolysis; SpeB; internalization; virulence; protein F1; Streptococcus pyogenes; fibronectin;

   Sammanfattning : The bacterial surface can be thought of as the interface where pathogenic bacteria encounter the human host. Interactions between bacterial surface proteins and human proteins are important determinants of the eventual outcome of infection. LÄS MER

4. 3. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations

   Författare :Kristina Berggren; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cysteine protease inhibition; ; IdeS; SpeB; Papain; ; Conformational restriction; Peptidomimetics;

   Sammanfattning : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. LÄS MER

5. 4. Streptococcus pyogenes secreted enzymes interacting with the human host

   Författare :Mattias Collin; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA fingerprinting; Streptococcus pyogenes; Clinical biology; immunoglobulins; Klinisk biologi; autoimmunity; endoglycosidase; cysteine proteinase; glycosylation;

   Sammanfattning : Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. LÄS MER

7. 5. Host-pathogen interactions in severe group A streptococcal infections

   Författare :Pontus Thulin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Streptococcus pyogenes, also called group A Streptococcus (GAS), is an important human pathogen ranked number 9 on the list of global killer pathogens. It causes a wide spectrum of disease, including uncomplicated superficial infections of the skin and throat, to life-threatening invasive infections and post-streptococcal sequelae. LÄS MER