Sökning: "IdeS"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet IdeS.

  1. 1. Studies on secreted cysteine proteases of Streptococcus pyogenes : IdeS and SpeB

    Författare :Reine Vindebro; Ulrich von Pawel-Rammingen; Wolfgang Knecht; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Streptococcus pyogenes; Group A Streptococci; GAS; virulence factor; IdeS; SpeB; cysteine protease; protease inhibitor; IgG; immune evasion; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

    Sammanfattning : The pathogen Streptococcus pyogenes is a significant cause of human morbidity and mortality. Most of the work in this thesis is focused on streptococcal virulence factor IdeS, but the thesis also features work on SpeB, another streptococcal virulence factor. LÄS MER

  3. 2. The streptococcal IgG degrading enzyme IdeS : studies on host-pathogen interactions

    Författare :Jenny Johansson Söderberg; Ulrich von Pawel-Rammingen; Jan Ingemar Flock; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; streptococcus pyogenes; IdeS; molekylärbiologi; Molecular Biology;

    Sammanfattning : The important human pathogen Streptococcus pyogenes causes both mild infections such as pharyngitis and impetigo but also severe life threatening invasive infections.  Specific antibodies (IgG) recognize pathogens and are important mediators for pathogen clearance by the immune defence. S. LÄS MER

  4. 3. Streptococcal immunoglobulin degrading enzymes of the IdeS and IgdE family

    Författare :Christian Spoerry; Ulrich von Pawel-Rammingen; Heiko Herwald; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Streptococcus; S. pyogenes; S. agalactiae; S. suis; S. porcinus; S. pseudoporcinus; S. equi subsp. zooepidemicus; protease; immunoglobulin; immune evasion; IdeS; IgdE; molekylärbiologi; Molecular Biology;

    Sammanfattning : Bacteria of the genus Streptococcus are common asymptomatic colonisers of humans and animals. As opportunistic pathogens they can however, depending on their host’s immune status and other circumstances, cause mild to very severe infections. LÄS MER

  5. 4. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations

    Författare :Kristina Berggren; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cysteine protease inhibition; ; IdeS; SpeB; Papain; ; Conformational restriction; Peptidomimetics;

    Sammanfattning : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. LÄS MER

  7. 5. Analysis of the molecular interplay between Streptococcus pyogenes and its human host

    Författare :Björn Johansson; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; bacteriology; virology; mycology; Biomedicinska vetenskaper allmänt ; Regulation; General biomedical sciences; IdeS; Enzyme; Virulence factors; Virulence; Bacteria; Streptococci; bakteriologi; virologi; mykologi; GAS; Protein; Mikrobiologi;

    Sammanfattning : The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. LÄS MER