Sökning: "Ribonucleotide reductase"

Visar resultat 6 - 10 av 77 avhandlingar innehållade orden Ribonucleotide reductase.

  1. 6. Biophysical studies of ribonucleotide reductase

    Författare :Margareta Sahlin; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : Ribonucleotide reductase (EC 1.17.4) catalyses the enzymatic reduction of ribonucleotides to their corresponding deoxyribo- nucleotides, the monomeric precursors for the DNA synthesis in all living cells. All ribonucleotide reductases so far Isolated from different species have been found to contain metal ions, either iron, cobolt or manganese. LÄS MER

  3. 7. Structural Studies of Proteins involved in Nucleotide Metabolism : Studies of a ribonucleotide reductase from A. aeolicus and NUDT15

    Författare :Daniel Rehling; Pål Stenmark; Gisela Brändén; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; ribonucleotide reductase; NUDT15; Biochemistry; biokemi;

    Sammanfattning : This thesis is separated into two parts. The first part concerns ribonucleotide reductase from Aquifex aeolicus. A. aeolicus is a hyperthermophilic bacterium that thrives at extremely high temperatures of 80-95 °C. LÄS MER

  4. 8. The evolution of ribonucleotide reductases

    Författare :Daniel Lundin; Anthony Poole; Britt-Marie Sjöberg; Christos Ouzounis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; ribonucleotide reductase; horizontal gene transfer; phylogeny; protein classification; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Ribonucleotide reductase (RNR) catalyses the transformation of RNA building blocks, ribonucleotides, to DNA building blocks, deoxyribonucleotides. This is the only extant reaction pathway for de novo synthesis of DNA building blocks and the enzyme is thus necessary for life. RNR is found in all but a few organisms. LÄS MER

  5. 9. Biophysical investigations of ribonucleotide reductase : Activation and inhibition mechanisms

    Författare :Maria Öhrström; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

    Sammanfattning : Ribonucleotide reductase (RNR) is the enzyme responsible for de novo synthesis of deoxyribonucleotides, needed for both synthesis and repair of cellular DNA. The RNRs known so far are divided into three distinct classes; I, II and III. The conventional class I enzyme is composed of two separate subunits. LÄS MER

  7. 10. Ribonucleotide reductase from Escherichia coli : structural aspects of protein function

    Författare :Anders Åberg; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER