Sökning: "Ribonucleotide reductase"
Visar resultat 16 - 20 av 77 avhandlingar innehållade orden Ribonucleotide reductase.
16. Activation and inhibition of diiron and iron-manganese ribonucleotide reductases
Sammanfattning : Ribonucleotide reductase (RNR) catalyses the reduction of ribonucleotides to deoxyribonucleotides. In conventional class I RNRs the active site is located in the R1 subunit, and the R2 subunit contains a diiron cofactor and a stable tyrosyl radical essential for activity. LÄS MER
17. Development and Application of Computational Methods in Antitubercular Drug Design : Identification of Novel Inhibitors of Ribonucleotide Reductase
Sammanfattning : Tuberculosis kills approximately 1.7 million people each year around the world making it one of the most lethal infectious diseases. This thesis concerns the development of two computational tools that can support the early stages of drug discovery, and their use in an anti-tubercular drug discovery program. LÄS MER
18. Radical generation and transfer in ribonucleotide reductase
Sammanfattning : .... LÄS MER
19. To reduce a ribonucleotide – Radical solutions in enzymology in form and function
Sammanfattning : It has been more than 50 years since the enzyme system ribonucleotide reductase (RNR), catalysing the reduction of ribonucleotides to deoxyribonucleotides, was first discovered. RNR was also the first time that radical chemistry was revealed in an enzyme. LÄS MER
20. Quaternary structure and interaction approaches to allosteric regulation of class I ribonucleotide reductases
Sammanfattning : Deoxyribonucleic acid (DNA) chains in which our genetic blueprint is stored are built from four DNA precursors by DNA polymerases. The enzyme ribonucleotide reductase (RNR) provides the only de novo synthesis pathway of deoxyribonucleotides from ribonucleotides and is essential for nearly all organisms. LÄS MER
