Sökning: "membrane-trafficking"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet membrane-trafficking.

1. 1. The Role of Membrane Trafficking in G Protein-Coupled Receptor Regulation

   Författare :Johan Enquist; Drug Target Discovery; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; downregulation; recycling; resensitization; desensitization; GPCR; membrane trafficking;

   Sammanfattning : Movements of a receptor in the plasma membrane and within the cell influence receptor function and physiology. I have investigated the role of such movements, generally known as membrane trafficking, in G protein-coupled receptor regulation. LÄS MER

3. 2. RICH-1, a Multifunctional RhoGAP Domain-containing Protein, Involved in Regulation of the Actin Filament System and Membrane-trafficking

   Författare :Ninna Richnau; Pontus Aspenström; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Rho GTPase; RhoGAP; actin; BAR domain; membrane-trafficking; formin homology proteins; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : The Rho GTPases, which are related to the Ras family of proto-oncogenes, have been found to have important roles in regulating the morphogenic and migratory properties of eukaryotic cells. In addition, these proteins have been shown to regulate aspects of cell signaling, cell growth, cell division and cell survival. LÄS MER

4. 3. Molecular mechanisms of biphasic insulin secretion

   Författare :Nikhil R. Gandasi; Sebastian Barg; Christien Merrifield; Uppsala universitet; []
   Nyckelord :Exocytosis; Insulin secretion; Membrane trafficking; Microscopy; Diabetes; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Pancreatic beta-cells secrete insulin in response to increase in blood glucose concentration with a rapid first phase and slower, sustained second phase. This secretion pattern is similar in entire pancreas, isolated islets of Langerhans and single beta-cells and it is disrupted in type 2-diabetes. LÄS MER

5. 4. Membrane-bound proteins : Characterization, evolution, and functional analysis

   Författare :Misty M. Attwood; Helgi B. Schiöth; Arne Elofsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transmembrane protein; alpha-helical membrane protein; evolution membrane proteins; 3TM; 4TM; 5TM; trispanin; Bioinformatics; Bioinformatik;

   Sammanfattning : Alpha-helical transmembrane proteins are important components of many essential cell processes including signal transduction, transport of molecules across membranes, protein and membrane trafficking, and structural and adhesion activities, amongst others. Their involvement in critical networks makes them the focus of interest in investigating disease pathways, as candidate drug targets, and in evolutionary analyses to identify homologous protein families and possible functional activities. LÄS MER

7. 5. The role of RhoD in actin dynamics, receptor trafficking and cancer cell migration

   Författare :Vishal Nehru; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The Ras subfamily of Rho GTPases plays an important role in myriads of cell processes, such as actin cytoskeleton dynamics, membrane trafficking and cell migration. Additionally, they also participate in diverse signal transduction pathways that regulate gene transcription, cell survival and cell growth. LÄS MER