Sökning: "RAGE"

Visar resultat 6 - 10 av 32 avhandlingar innehållade ordet RAGE.

  1. 6. Diabetes and peripheral arterial disease

    Författare :Jonas Malmstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Diabetes mellitus increases the risk for peripheral arterial disease (PAD) early in life and the disease is likely to progress to advanced stages. Mechanisms responsible for premature PAD in diabetes are partly unknown. LÄS MER

  3. 7. The inflammatory and immunogenic properties of the receptor for advanced glycation end products and its ligand, high mobility group box chromosomal protein 1

    Författare :Rille Pullerits; Göteborgs universitet; []
    Nyckelord :HMGB1; sRAGE; rheumatoid arthritis; inflammation; cytokines;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic systemic inflammatory joint disease, the pathogenesis of which is complex, involving a wide range of molecules. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein recently recognised as a pro-inflammatory cytokine which levels are increased in RA patients. LÄS MER

  4. 8. Characterisation of HMGB1 in inflammation

    Författare :Therese Östberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : High mobility group box chromosomal protein 1 (HMGB1) was discovered over three decades ago as a nuclear protein which is present in all mammalian nucleated cells. Subsequent studies have revealed additional properties of HMGB1 besides its originally described nuclear functions. LÄS MER

  5. 9. On the importance of inflammation for personality traits and psychiatric morbidity

    Författare :Petra Suchankova; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; C-reactive protein; complement factor H; S100B; receptor for advanced glycation end products; polymorphism; gene expression; personality traits; suicidal behaviour; schizophrenia; depression; Flinders sensitive line;

    Sammanfattning : Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. LÄS MER

  7. 10. Preterm and term cervical ripening : studies on CRH, HMGB1, toll-like receptors, cytokines and matrix metalloproteinases

    Författare :Aurelija Dubicke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical fibroblasts; cervical ripening; cervix; chemokines; cytokines; CRH; HMGB1; interleukin; labor; preterm; preterm labor; matrix metalloproteinases; pregnancy; PPROM; Tolllike receptors;

    Sammanfattning : Objective: Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. Despite the existing treatment, the frequency of PTB has not changed in the past thirty years. Incomplete understanding of the biological and pathophysiological mechanisms underlying preterm delivery is the major obstacle to preventing PTB. LÄS MER