Sökning: "QTL Analysis"

Visar resultat 31 - 35 av 52 avhandlingar innehållade orden QTL Analysis.

  1. 31. Molecular genetics of type 2 diabetes

    Författare :Li Luosheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes; the Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; high fat diet; disease progression; alternative splicing; comparative genomics.;

    Sammanfattning : Type 2 diabetes is a common and chronic disease caused by interactions between genetic and environmental factors. The Goto-Kakizaki (GK) rat is a well-established genetic model of type 2 diabetes. LÄS MER

  3. 32. Population level genome-wide association studies in dairy cattle

    Författare :Xiaowei Mao; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In recent years, genome-wide association studies (GWAS) has become a dominant tool for detecting genetic architectures for complex traits. Thousands of associated genetic variants have been reported. However, the resolution of these studies was limited by the available marker density for the quantitative trait loci (QTL) region. LÄS MER

  4. 33. Gene mapping of reproduction traits in dairy cattle

    Författare :Johanna Karolina Höglund; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : In this thesis my aims were to map genes affecting reproduction in cattle and to explore the correlated effect of these genes on yield traits. This knowledge is expected to provide novel insights into the biological processes underlying reproduction traits and to identify individual causal polymorphisms or genetic markers for practical application in marker-assisted and genomic selection strategies. LÄS MER

  5. 34. Development of Variance Component Methods for Genetic Dissection of Complex Traits

    Författare :Francois Besnier; Örjan Calborg; Miguel Perez-Enciso; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; Genetik; Genetics;

    Sammanfattning : This thesis presents several developments on Variance component (VC) approach for Quantitative Trait Locus (QTL) mapping. The first part consists of methodological improvements: a new fast and efficient method for estimating IBD matrices, have been developed. LÄS MER

  7. 35. Quantitative Genetics and Genomic Selection of Scots pine

    Författare :Ainhoa Calleja-Rodriguez; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : The final objective of tree improvement programs is to increase the frequency of favourable alleles in a population, for the traits of interest within the breeding programs. To achieve this, it is crucial to decompose the phenotypic variance accurately into its genetic and environmental components in order to obtain a precise estimation of genetic parameters and to increase genetic gains. LÄS MER