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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC

   Författare :Robert Arnell; Torgny Fornstedt; Andreas Seidel-Morgenstern; Uppsala universitet; []
   Nyckelord :Analytical chemistry; Liquid chromatography; Preparative LC; Chiral LC; Multi-component LC; Adsorption isotherm; Tracer-pulse method; Inverse method; Inverse method on plateaus; Peak deformations; Chiral drug-protein interactions; Analytisk kemi;

   Sammanfattning : This thesis concerns the development and validation of methods for characterization of multi-component preparative LC systems. Measurements of competitive adsorption isotherms are performed to gain detailed information about the interactions inside the chromatography column. LÄS MER

3. 2. Fundamental Investigations of Supercritical Fluid Chromatography

   Författare :Martin Enmark; Torgny Fornstedt; Arvind Rajendran; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Supercritical Fluid Chromatography; SFC; Modeling; Adsorption Isotherms; Scale-up; Peak Distortion; Injection; Design of Experiments; Perturbation Peak Method; Elution by Characteristic Points Method; Method transfer; Kemi; Chemistry;

   Sammanfattning : This thesis aims at a deeper understanding of Supercritical FluidChromatography (SFC). Although preparative SFC has started to replace Liquid Chromatography (LC) in the pharmaceutical industry - because of its advantages in speed and its less environmental impact - fundamental understanding is still lacking. LÄS MER

4. 3. Mass spectrometry in peptide and tumor marker analysis

   Författare :Ann-Charlotte Bergman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Integration of preparative protein and peptide separations with analytical techniques, in particular mass spectrometry (MS), is important. This thesis describes preparation via capillary electrophoresis and two-dimensional (2-D) gel electrophoresis for identification and structure determination of polypeptides. LÄS MER

5. 4. Mass spectrometry-based proteomic strategies applied to Helicobacter pylori. A Search for candidate vaccine antigens

   Författare :Elisabet Carlsohn; Göteborgs universitet; []
   Nyckelord :proteomics; mass spectrometry; Helicobacter pylori; membrane proteins; nano-liquid chromatography; subcellular fractionation;

   Sammanfattning : This thesis describes the development and refinement of proteomic strategies and the application of these on the human gastric pathogen H. pylori. The purpose was to identify proteins, and in particular membrane proteins, as potential targets for vaccine development. LÄS MER

7. 5. Packed Column Supercritical Fluid Chromatography : Applications in Environmental Chemistry

   Författare :Nicole Riddell; Bert van Bavel; Robert McCrindle; Ingrid Ericson Jogsten; Jake Ryan; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Supercritical Fluid Chromatography; Mass Spectrometry; Ionization; POPs; APPI; APCI; chiral; achiral; packed column;

   Sammanfattning : Although gas and liquid chromatography have emerged as dominant separation techniques in environmental analytical chemistry, these methods do not allow for the concurrent analysis of chemically diverse groups of persistent organic pollutants (POPs). There are also a small number of compounds which are not easily amenable to either of these traditional separation techniques. LÄS MER