Sökning: "Perturbation Peak Method"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Perturbation Peak Method.

  1. 1. Fundamental Investigations of Supercritical Fluid Chromatography

    Författare :Martin Enmark; Torgny Fornstedt; Arvind Rajendran; Karlstads universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Supercritical Fluid Chromatography; SFC; Modeling; Adsorption Isotherms; Scale-up; Peak Distortion; Injection; Design of Experiments; Perturbation Peak Method; Elution by Characteristic Points Method; Method transfer; Kemi; Chemistry;

    Sammanfattning : This thesis aims at a deeper understanding of Supercritical FluidChromatography (SFC). Although preparative SFC has started to replace Liquid Chromatography (LC) in the pharmaceutical industry - because of its advantages in speed and its less environmental impact - fundamental understanding is still lacking. LÄS MER

  3. 2. Adsorption Isotherm Parameter Estimation in Nonlinear Liquid Chromatography

    Författare :Patrik Forssén; Bertil Gustafsson; Torgny Fornstedt; Georges Guiochon; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; High performance liquid chromatography HPLC ; Preparative chromatography; Competitive adsorption isotherm parameters; Perturbation peak PP method; Inverse method IM ; Computer simulation; Parameter estimation; Numerical method; Scientific Computing; Beräkningsvetenskap;

    Sammanfattning : This thesis concerns the development and validation of methods for the industrially important area of adsorption isotherm parameter estimation in preparative, nonlinear high performance liquid chromatography (HPLC). Preparative chromatography is a powerful separation method to get pure compounds from more or less complex liquid mixtures, e.g. LÄS MER

  4. 3. Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC

    Författare :Robert Arnell; Torgny Fornstedt; Andreas Seidel-Morgenstern; Uppsala universitet; []
    Nyckelord :Analytical chemistry; Liquid chromatography; Preparative LC; Chiral LC; Multi-component LC; Adsorption isotherm; Tracer-pulse method; Inverse method; Inverse method on plateaus; Peak deformations; Chiral drug-protein interactions; Analytisk kemi;

    Sammanfattning : This thesis concerns the development and validation of methods for characterization of multi-component preparative LC systems. Measurements of competitive adsorption isotherms are performed to gain detailed information about the interactions inside the chromatography column. LÄS MER

  5. 4. On Multistage Analysis of Transonic Compressors: From Axisymmetric Throughflow Time-Marching to Unsteady Three-Dimensional Methods

    Författare :Stephane Baralon; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; shock; time-marching; deterministic; average-passage; multistage; fan; axisymmetric; 3D; unsteady; transonic; viscous; body force; stress; singularity; perturbation; throughflow; mixing-plane; modelling; finite-volume;

    Sammanfattning : A throughflow time-marching finite-volume solver, capable of computing viscous transonic multistage compressor flows with embedded shocks, is presented. The behavior of the blade model, based on the blade mean surface flow tangency condition, was investigated for transonic flows. LÄS MER

  7. 5. Development and Validation of HPLC Methods for Analytical and Preparative Purposes

    Författare :Johan Lindholm; Torgny Fornstedt; Karin Caldwell; Karl-Gustaf Wahlund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; High performance liquid chromatography HPLC ; Analytical biotechnology; Sample preparation; Diode-array-detection DAD ; Mass spectrometry MS ; Validation; Preparative chromatography; Competitive isotherm parameters; Perturbation peak PP method; Kemi; Chemistry; Kemi;

    Sammanfattning : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. LÄS MER