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Visar resultat 1 - 5 av 47 avhandlingar som matchar ovanstående sökkriterier.
1. Calmodulin mediated regulation of NF-kappaB in lymphocytes
Sammanfattning : NF-κB transcription factors are regulators of a wide spectrum of genes involved in immune responses and inflammation as well as cellular proliferation and survival. Transcriptionally competent NF-κB dimers are retained in the cytoplasm of resting cells by binding to inhibitors of NF-κB (IκBs). LÄS MER
2. NF-kappaB in skin immune homeostasis and cancer development
Sammanfattning : The outermost part of the skin, the epidermis, is built up by cells called keratinocytes. The epidermis provides a vital barrier between the body and the outer world. It is also a target for constant physical and microbial injury. LÄS MER
3. Tumor biological aspects of the mucin-like glycoprotein CD43
Sammanfattning : Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. CD43, a type I transmembrane protein, is a mucin-like molecule expressed under normal physiological conditions by most hematopoietic cell types. LÄS MER
4. Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease
Sammanfattning : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local protective response to prevent thrombus extension. LÄS MER
5. Relish and the Regulation of Antimicrobial Peptides in Drosophila melanogaster
Sammanfattning : The fruit fly Drosophila melanogaster has been a powerful model system in which to study the immune response. When microorganisms breach the mechanical barrier of the insect, phagocytosing cells and a battery of induced antimicrobial molecules rapidly attack them. These antimicrobial peptides can reach micromolar concentrations within a few hours. LÄS MER
