Sökning: "p65"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet p65.

  1. 1. Tumor biological aspects of the mucin-like glycoprotein CD43

    Författare :Sirle Laos; Göteborgs universitet; []
    Nyckelord :CD43; leukosialin; sialophorin; mucin; colon adenoma; proteolytic processing; ; NF-kappaB; p65; chemokine; p53; ARF; Fas; apoptosis; transformation;

    Sammanfattning : Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. CD43, a type I transmembrane protein, is a mucin-like molecule expressed under normal physiological conditions by most hematopoietic cell types. LÄS MER

  3. 2. Polymorphism and expression of NF-κB in relation to susceptibility and prognosis of colorectal cancer patients

    Författare :Andreas Lewander; Xiao-Feng Sun; Bengt Gustavsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Normal human cells are strictly controlled in their environment by extrinsic and intrinsic factors. Despite this, some cells begin to develop into cancer cells, and if this process is allowed to continue, it will develop into cancer disease. To become cancerous, a cell must break several biological barriers. LÄS MER

  4. 3. Structure-aided design of antiviral drugs : Application of the method on HIV-1 protease and SIV reverse transcriptase

    Författare :Hans Ola Andersson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; HIV; protease; SIV; reverse transcriptase; structure; inhibitor; drug design; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Many efforts have been made to control the AIDS epidemic. Extensive studies have been done on the biology, biochemistry, and structural biology of HIV in the search for antiviral drugs. The viral-encoded enzymes reverse transcriptase and protease have been main targets for drug design. LÄS MER

  5. 4. Structural studies on cytochrome bc1 complex from bovine heart mitochondria

    Författare :Momi Iwata; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Ubiquinol:cytochrome c oxidoreductase; membrane protein; X-ray crystallography; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : The cytochrome bc1 complex (Ubiquinol:Cytochrome c oxidoreductase or Complex III) is an enzyme of the mitochondrial respiratory chain, crucial for aerobic metabolism. This enzyme catalyses the electron transfer from membrane-bound ubiquinol to soluble cytochrome c. LÄS MER

  7. 5. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay

    Författare :Linda Arngården; Ola Söderberg; Niclas Karlsson; Uppsala universitet; []
    Nyckelord :cell signaling; Wnt; Hippo; TGFB; Molekylär medicin; Molecular Medicine;

    Sammanfattning : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. LÄS MER