Sökning: "Relish"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Relish.

  1. 1. Relish and the Regulation of Antimicrobial Peptides in Drosophila melanogaster

    Författare :Marika Hedengren Olcott; Barbara Taylor; Jean-Marc Reichhart; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila immunity; NF-kappaB; Relish; antimicrobial peptides; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : The fruit fly Drosophila melanogaster has been a powerful model system in which to study the immune response. When microorganisms breach the mechanical barrier of the insect, phagocytosing cells and a battery of induced antimicrobial molecules rapidly attack them. These antimicrobial peptides can reach micromolar concentrations within a few hours. LÄS MER

  3. 2. Peptidoglycan recognition proteins in Drosophila melanogaster

    Författare :Thomas Werner; Dan Hultmark; Bruno Lemaitre; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Drosophila; PGRP; peptidoglycan; pattern recognition; imd; Relish; isoform; RNAi; mbn-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The fruit fly Drosophila melanogaster is an excellent model organism to study the innate immune response, because insects and mammals share conserved features regarding the recognition and destruction of microorganisms and Drosophila is easily accessible to genetic manipulation. In my present study, I identified a new family of pattern recognition molecules for bacterial peptidoglycan in Drosophila, the Peptidoglycan Recognition Proteins (PGRP). LÄS MER

  4. 3. Stress- and immune defence in Drosophila melanogaster

    Författare :Sophia Ekengren; Robert DeLotto; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Zoological Developmental Biology; zoologisk utvecklingsbiologi;

    Sammanfattning : Many cellular responses are regulated at the transcriptional level. Newly synthesized proteins and peptides rapidly exert their function at the time of expression, as a response to different environmental cues. LÄS MER

  5. 4. Regulation of antimicrobial peptide gene expression in Drosophila melanogaster : Involvement of POU and NF-kB/Rel factors in innate immunity

    Författare :Anna Junell; Ylva Engström; Jean-Luc Imler; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The fruit fly, Drosophila melanogaster, has a well-developed immune response, and microbial assault induces a rapid production of potent antimicrobial peptides (AMPs). The aim of this thesis work was to gain deeper knowledge of the regulation of AMPs in Drosophila, by the isolation and characterization of transcription factors involved in AMP gene expression. LÄS MER

  7. 5. Isoform-specific regulation of Drosophila gut immunity and regeneration by the POU/Oct transcription factor Nub/Pdm1

    Författare :Xiongzhuo Tang; Ylva Engström; Tony Ip; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; POU; Nubbin; Drosophila; intestinal stem cell; epithelium regeneration; midgut; mitosis; Antimicrobial peptides; innate immunity; NF-κB; bacterial infection; transcriptional regulation; homeostasis; Molecular Biology; molekylärbiologi;

    Sammanfattning : Innate immune reactions protect organisms against a variety of infections.  In metazoans, these reactions involve both cellular and humoral responses. The immune responses have to be well-tuned, as excessive immune activation is associated with tissue-specific pathologies. LÄS MER