Sökning: "NADPH-oxidase"

Visar resultat 6 - 10 av 55 avhandlingar innehållade ordet NADPH-oxidase.

  1. 6. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors

    Författare :Andris Elksnis; Per-Ola Carlsson; Nils Welsh; Sergiu-Bogdan Catrina; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; Tyrosine kinase inhibitors; Imatinib; AMPK; Oxidative stress; NADPH-oxidase; NOX; NOX4; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. LÄS MER

  3. 7. Study of molecular mechanism(s) underlying neurodegeneration in SCA7 disease : Role of NOX enzymes and oxidative stress

    Författare :Abiodun Ajayi; Anna-Lena Ström; Boris Zhivotosky; Bengt Mannervik; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurodegeneration; polyglutamine; oxidative stress; metabolism; NADPH oxidase; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the SCA7/ATXN7 gene resulting in progressive ataxia and retinal dystrophy. SCA7 belongs to a group of neurodegenerative disorders called polyglutamine (polyQ) diseases, that share the common feature of glutamine tract expansions within otherwise unrelated proteins. LÄS MER

  4. 8. Genetic and genomic analysis of arthritis regulating regions in human and mouse

    Författare :Lina Olsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Immunologi; serologi; transplantation; Skeleton; muscle system; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; QTL; NADPH oxidase complex; Rheumatoid Arthritis; Genetic Analysis;

    Sammanfattning : Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. LÄS MER

  5. 9. NADPH oxidase and xanthine oxidoreductase as targets and regulators of the nitrate-nitrite-nitric oxide pathway

    Författare :Maria Peleli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) and xanthine oxidoreductase (XOR) with a concomitant decrease in the bioavailability of nitric oxide (NO) from eNOS contributes to the development of cardiovascular and metabolic disorders. Extensive research has proven the existence of an alternative NOS-independent pathway for NO production. LÄS MER

  7. 10. Studies on Two Proteins with Potential Implications for Atherosclerosis. Lipolytic Enzyme Carboxyl Ester Lipase and Nadph Oxidase Subunit NOX4

    Författare :Sara Ellmark; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER