Sökning: "Meningococcal Disease"

Visar resultat 11 - 15 av 15 avhandlingar innehållade orden Meningococcal Disease.

  1. 11. RNA-mediated gene regulation in Neisseria meningitidis and other nasopharyngeal pathogens

    Författare :Hannes Eichner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neisseria meningitidis is a transient commensal bacterium of the upper respiratory tract and spreads through respiratory secretions produced by the carrier. While mostly harmless, the bacterium can cause invasive meningococcal disease by entering the circulatory system, leading to septicaemia and/or meningitis. LÄS MER

  3. 12. Hfq- and sRNA-mediated regulation in Neisseria meningitidis

    Författare :Jens Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal epithelium and enter the bloodstream, causing invasive meningococcal disease manifesting in septicaemia and/or meningitis. LÄS MER

  4. 13. Host responses and bacterial virulence factors in Neisseria infections

    Författare :Linda Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neisseria; CD46; LPS; antimicrobial peptide.;

    Sammanfattning : Neisseria meningitidis and Neisseria gonorrhoeae are human specific pathogens. N. meningitidis is a major cause of meningitis and sepsis, whilst N. gonorrhoeae causes many millions of cases of gonorrhea in the world every year. LÄS MER

  5. 14. Macrophage programming and host responses to bacterial infection

    Författare :Xiao Wang; Hong Sjölinder; Martin Rottenberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Macrophages; meningococci; mycobacteria; NhhA; CD46; cytokines; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Macrophages are dynamic, plastic, and heterogeneous immune cells that play an important role in host immune defense against bacterial infection. Various bacterial pathogens, such as Neisseria meningitidis and Mycobacterium tuberculosis, can modulate host immune responses by interfering with macrophage differentiation and polarization. LÄS MER

  7. 15. Primary immunodeficiency in southern Sweden. Strategies for diagnosis and clinical management

    Författare :Nicholas Brodszki; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune system; Lymphocytes; T-cell; B-cell; Antibodies; Complement system; Epidemiological study; Primary immunodeficiency; Severe combined immunodeficiency; Hematopoietic stem cell transplantation;

    Sammanfattning : The overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identified cases. LÄS MER