Sökning: "Mechanistic studies"

Visar resultat 21 - 25 av 465 avhandlingar innehållade orden Mechanistic studies.

  1. 21. Design, Synthesis, Mechanistic Rationalization and Application of Asymmetric Transition-Metal Catalysts

    Författare :Christian Hedberg; Pher G. Andersson; Hans-Ulrich Blaser; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; asymmetric catalysis; homogeneous hydrogenation; iridium; ruthenium; ligand design; mechanistic studies; kinetics; tolterodine; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes mechanistic studies, rational ligand design, and synthesis of asymmetric transition metal catalysts. The topics addressed concerned [Papers I-VII]:[I] The asymmetric addition of diethyl zinc to N-(diphenylphosphinoyl)benzalimine catalyzed by bicyclic 2-azanorbornyl-3-methanols was studied. LÄS MER

  3. 22. Mechanistic studies of APR-246 in leukemia

    Författare :Dina Mahmoud Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : PRIMA-1 and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore the effects of APR-246 alone and in combination with other drugs in acute myeloid leukemia (AML) in vitro. LÄS MER

  4. 23. Ruthenium-Catalyzed Hydrogen Transfer Reactions : Mechanistic Studies and Chemoenzymatic Dynamic Kinetic Resolutions

    Författare :Madeleine Warner; Jan-Erling Bäckvall; Andreas Pfaltz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hydrogen transfer; ruthenium catalysis; kinetic resolution; dynamic kinetic resolution; racemization; asymmetric synthesis; organisk kemi; Organic Chemistry;

    Sammanfattning : The main focus of this thesis lies on transition metal-catalyzed hydrogen transfer reactions. In the first part of the thesis, the mechanism for racemization of sec-alcohols with a ruthenium complex, Ru(CO)2Cl(η5-C5Ph5) was studied. LÄS MER

  5. 24. Enols and Allylic Alcohols as Building Blocks in Synthetic Organic Chemistry : Experimental and Theoretical Studies

    Författare :Alba Carretero Cerdán; Belén Martín‐Matute; Shu-Li You; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Base catalysis; Ion-pair; Isomerization; MOFs; Hypervalent Iodine III ; DFT; Organic Chemistry; organisk kemi;

    Sammanfattning : The present thesis describes computational and experimental studies used to drive the reactivity of allylic and enol substrates towards new transformations. These synthetic methods give access to a number of organic molecules that may serve as important moieties in synthetic organic chemistry. LÄS MER

  7. 25. Mechanistic Studies of Dinuclear Metalloenzymes - A Model Approach

    Författare :Håkan Carlsson; Kemiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; models; Enzymes; bioinorganic chemistry; dinuclear; urease; nickel; zinc triphosphoesterase; Oorganisk kemi; Inorganic chemistry;

    Sammanfattning : With the goal to study the mechanisms of dinuclear metalloenzymes, a new line of synthetic and computational models were prepared and studied. Mixed imidazole and carboxylate multidentate complexes were synthesized to better simulate carboxylate-rich ligand environments. LÄS MER