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Visar resultat 1 - 5 av 10 avhandlingar som matchar ovanstående sökkriterier.
1. Development of new mimetics for b-hairpins. Synthesis, structure and conformation
Sammanfattning : .... LÄS MER
2. Towards the Development of Photoswitchable β-Hairpin Mimetics
Sammanfattning : Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogeneous peptides with new physicochemical and pharmacological properties. The β-hairpin motif has been shown to be involved in numerous physiological processes, among others in regulation of eucariotic gene transcription. LÄS MER
3. Development of phosphorus-containing metallo-β-lactamase inhibitors : Synthesis and binding studies by solution NMR and molecular docking
Sammanfattning : The rapidly growing bacterial resistance development is turning into one of the main challenges of the 21st century. Our antibiotics are becoming ineffective for the treatment of bacterial infections, and without successful action, simple infections, such as pneumonia or Septicemia, will soon carry a highly probable mortal prognosis. LÄS MER
4. Phosphonamidates as potential NDM-1 inhibitors
Sammanfattning : WHO’s recent reports indicate that the rapidly growing resistance of bacteria became one of the biggest problems of the XXI century. The most powerful human counter weapon, antibiotics, starts to become ineffective for the treatment of bacterial infections. LÄS MER
5. Characterising Halogen Bonding in a Cooperative Model System
Sammanfattning : Non-covalent interactions are the main driving factor for secondary structure formation of biomacromolecules and are of enormous importance for the direction of molecular recognition events, for example those of importance for drug discovery. Profound understanding of these interactions is of vital importance to achieve high affinity and selectivity of a ligand to a chosen target. LÄS MER
