Avancerad sökning

Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Effects of immunosuppressive drugs on human adipose tissue metabolism

   Författare :Maria J Pereira; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

   Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER

3. 2. Estrogen and its receptors in adipose tissue from women and men : Associations with age, adiposity and type 2 diabetes

   Författare :Fozia Ahmed; Jan Eriksson; Maria J. Pereira; Susanne Hetty; Karin Stenkula; Uppsala University; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; estrogen; estrogen receptors; menopause; obesity; insulin resistance; type 2 diabetes.;

   Sammanfattning : Obesity and its complications, such as insulin resistance and type 2 diabetes (T2D), are leading causes of morbidity and mortality globally. Adipose tissue is important for whole-body homeostasis, functioning as an energy storage reservoir and an endocrine organ. LÄS MER

4. 3. Metabolic and endocrine effects of SGLT2 inhibition

   Författare :Per Lundkvist; Jan Eriksson; Lars Lind; Maria J Pereira; Michael Alvarsson; Uppsala universitet; []
   Nyckelord :SGLT2 inhibition; GLP-1 receptor agonism; DPP4 inhibition; NAFLD; prediabetes; type 2 diabetes; obesity; metabolic syndrome; glucagon.; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Obesity and type 2 diabetes (T2D) are two growing global health problems with similar comorbidity profiles. SGLT2 inhibitors (SGLT2i) improve blood glucose control and can relieve both T2D and obesity, as well as their associated health problems such as hypertension, kidney failure, and cardiovascular disease. LÄS MER

5. 4. Pharmacological and genetic manipulation of adipose cell differentiation and metabolism

   Författare :Milica Vranic; Maria J. Pereira; Jan Eriksson; Niklas Mejhert; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; adipocyte; type 2 diabetes; CRISP Cas9; FKBP51; CDKN2C; second-generation antipsychotics; glucocorticoids; dopamine; dopamine receptor;

   Sammanfattning : Adipose tissue dysfunction has a pivotal role in the development of obesity and related metabolic complications, such as insulin resistance, cardiovascular disease, and diabetes. The overall aim was to study the consequences of adipose exposure to pharmacological agents, as well as dysregulations in the expression of genes, potentially involved in adipose tissue dysfunction and related metabolic impairments. LÄS MER