Sökning: "rapamycin"

Visar resultat 1 - 5 av 54 avhandlingar innehållade ordet rapamycin.

  1. 1. Effects of immunosuppressive drugs on human adipose tissue metabolism

    Författare :Maria J Pereira; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

    Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER

  3. 2. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

    Författare :Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
    Nyckelord :Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

    Sammanfattning : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. LÄS MER

  4. 3. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling

    Författare :Thomas Strömberg; Helena Jernberg Wiklund; Kenneth Nilsson; Anders Waage; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Multiple myeloma; IGF-IR; apoptosis; somatostatin; octreotide; dexamethasone; GSK-3; mTOR; rapamycin; RTK inhibitor; Patologi; Pathology; Patologi;

    Sammanfattning : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. LÄS MER

  5. 4. Drug Eluting Hydrogels : Design, Synthesis and Evaluation

    Författare :Lage Ahrenstedt; Deon Bezuidenhout; Michael Malkoch; University of Cape Town; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drug delivery; PEGylation; Rapamycin; Dexamethasone; Controlled release; Hydrogels; Slow release;

    Sammanfattning : Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. LÄS MER

  7. 5. Regulation of Renal Hyaluronan in Water Handling : Studies in vivo and in vitro

    Författare :Sara Stridh; Peter Hansell; Mats Rundgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; water balance; fluid handling; diabetes; nephropathy; ACE fetopathy; reabsorption; hyaluronic acid; glycosaminoglycan; GAG; extracellular matrix; mTOR; rapamycin; streptozotocin;

    Sammanfattning : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. LÄS MER