Sökning: "tacrolimus"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet tacrolimus.

  1. 1. Effects of immunosuppressive drugs on human adipose tissue metabolism

    Författare :Maria J Pereira; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

    Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER

  3. 2. Inhibition of acute allogaft rejection - experimental transplant studies with biological and chemical immunosuppressants

    Författare :Zhongquan Qi; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; tacrolimus; MNA; leflunomide; cyclosporine; drug effects; graft survival; immunosuppression; heart; animal; transplantation; Immunologi; serologi; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : In clinical transplantation immunosuppressive agents are used in combination with the objective to achieve additive effects and less toxicity. A large number of novel drugs are candidates for clinical introduction at this time and experiments in animal models have an important role to play. LÄS MER

  4. 3. Posttransplantational bone disease : the effect of immunosuppressive drugs on bone : clinical and experimental studies

    Författare :Mohamed Mohamed Abdelhadi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Liver transplantation; hyperparathyroidism; bone density; renal transplantation; cyclosporine; prednisolone; tacrolimus; statin; growth plate; rats;

    Sammanfattning : Osteoporosis and pathologic fractures are frequent complications ill patients with end-stage liver or kidney diseases. Although successful transplantation eliminates some factors related to poor organ function, all increased incidence of pathologic fractures was reported ill the early post-transplant period in spite of normalization of the allograft function. LÄS MER

  5. 4. Uterus transplantation: an experimental study in the rat model

    Författare :Shamima N Akhi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; infertility; microsurgery; pregnancy; rat; transplantation; uterus;

    Sammanfattning : One of the last frontiers to conquer in infertility research is to find a treatment for uterine factor infertility, which affects around 2500 Swedish women. These women cannot become pregnant or carry a pregnancy due to absence of uterus or presence of non-functioning uterus. LÄS MER

  7. 5. Intestinal transplantation. Experimental and clinical studies

    Författare :Mihai Oltean; Göteborgs universitet; []
    Nyckelord :Intestinal preservation; Ischemia-reperfusion injury; Tight junction; FK506; Resistin;

    Sammanfattning : Intestinal preservation-reperfusion injury may result in various degrees of mucosal injury. Interestingly, the preservation injury is similar when using the current preservation solutions, which are given as a intravascular flush. An extensive mucosal injury may ultimately preclude the use of organs that require longer preservation time. LÄS MER