Sökning: "Lentivirus"

Visar resultat 11 - 15 av 22 avhandlingar innehållade ordet Lentivirus.

  1. 11. Characterisation of nanobodies directed against emerging viruses

    Författare :Ainhoa Moliner-Morro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The emergence of new viral pathogens, such as SARS-CoV-2, or re-emergence of known pathogens, like CHIKV, point out the need for further understanding of the biology behind viruses, as well as the urgent need for the development of therapeutic and diagnostic tools. Nanobodies, small antigen-binding fragments derived from camelid heavy-chain antibodies, have gained attention for their use in viral research due to their wide range of applications: from the study of protein-protein interactions, uncovering of new viral targets, to the generation of new diagnostic tools or therapeutics. LÄS MER

  3. 12. Development of lentiviral vectors for CNS gene transfer

    Författare :Johan Jakobsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biotechnology; Gene Therapy; Neurological disorders;

    Sammanfattning : Gene therapy in the brain is a promising treatment strategy that in the future may be used for several brain disorders, including Parkinson's disease, Alzheimer's disease and lysosomal storage diseases. By introducing a new gene, rather than providing a classical pharmacological drug, gene therapy offers the opportunity to treat neurological disorders by a single intervention. LÄS MER

  4. 13. VEGFR-2 in Endothelial Differentiation and Vascular Organization

    Författare :Dan Edholm; Lena Claesson-Welsh; Xiujuan Li; Victoria Bautch; Uppsala universitet; []
    Nyckelord :Molecular medicine; Embryonic stem; VEGFR-2; Flk1; KDR; VEGF; vasculogenesis; angiogenesis; embryoid body; Molekylärmedicin;

    Sammanfattning : The cardiovascular system is the first functional organ to develop during embryogenesis. As the embryo reaches above a certain size, passive diffusion of gases and nutrients is no longer compatible with efficient growth. LÄS MER

  5. 14. Dynamics of the HIV-2-specific immunoglobulin A(IgA) response

    Författare :Qin Lizeng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human; HIV; Immunology; Pathogenesis; Antibodies IgA IgG; Epitopes; Neutralization;

    Sammanfattning : Millions of lives are affected by infection with HIV, which causes AIDS if untreated. HIV transmission occurs primarily through sexual contact across mucosal surfaces. In the mucosal immune response, IgA is considered the first defense line against HIV invasion. LÄS MER

  7. 15. Exploring the miRNA profile of medium spiny neurons using retrograde transport in rats

    Författare :Marcus Lockowandt; CNS Genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The basal ganglia play an essential role in movement selection and control. It is therefore not surprising that they are central to neurodegenerative diseases like Parkinson’s disease and Huntington’s disease. LÄS MER