Sökning: "Lentivirus"

Visar resultat 6 - 10 av 22 avhandlingar innehållade ordet Lentivirus.

  1. 6. Ultrasound-guided in utero lentivirus transduction of the murine nervous system to investigate nervous system disorders

    Författare :Katrin Mangold; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurodevelopment is a highly dynamic process involving hundreds of molecular different cell types. Gain and loss of function studies provide valuable insight into the gene regulatory networks that orchestrate this morphological process. LÄS MER

  3. 7. Humoral immunity during primate lentivirus infection : evaluation of B cell apoptosis and engineering of virus specific antibodies

    Författare :Astrid Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The focus of this project was to evaluate the contribution of the humoral immunity in controlling infection with primate lentiviruses - an area which has implications both for vaccine design as well as for understanding of the pathogenesis of the disease. The first goal was to generate efficient neutralizing reagents which could be used for passive immunotherapy trials, preferably in the macaque system, and to investigate if peptide immunogens could elicit such antibodies. LÄS MER

  4. 8. Modifying xenogeneic immune recognition and engraftment by genetic engineering

    Författare :Zhong He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Xenotransplantation; gene therapy; gene transfer; endothelium; promoters; monocytes; NK cells; alpha-Gal; lentivirus vectors; pancreatic islets;

    Sammanfattning : Transplantation using xenogenic organs, tissues and cells (i.e. xenotransplantation) is a potential solution to the shortage of those from human sources. Vascular endothelial cells (ECs) are the most immediate barrier between the xenogeneic donor organ and the host defense systems. LÄS MER

  5. 9. Improvement of adoptive T-cell therapy for Cancer

    Författare :Chuan Jin; Magnus Essand; Ola Winqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR T-cell therapy; AEP expansion protocol; scaffold matrix attachment region; non-integrating lentivirus; H. pylori Neutrophil-activating protein; allogeneic DCs; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Cancer immunotherapy has recently made remarkable clinical progress. Adoptive transfer of T-cells engineered with a chimeric antigen receptor (CAR) against CD19 has been successful in treatment of B-cell leukemia. LÄS MER

  7. 10. Lineage tracing of early organogenesis and liver mesenchymal cells with ultrasound-guided in utero nano-injection

    Författare :Jingyan He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Current methods used to investigate embryo development and alter gene expression in mouse embryos are often time consuming and require large numbers of mice. To circumvent these limitations, we were aiming to develop a flexible and efficient method to investigate embryo development and manipulate gene expression in utero. LÄS MER