Sökning: "Ischaemia"

Visar resultat 21 - 25 av 80 avhandlingar innehållade ordet Ischaemia.

  1. 21. Studies of myocardial ischaemia followed by reperfusion : new experimental models and their application

    Författare :Yozo Uriuda; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :myocardial infarction; myocardial ischaemia; reperfusion injury; animal experiment; rat; pig; dog; coronary venous retroinfusion; synchronised coronary venous retroperfusion; thrombosis; thrombolysis; inogatran; endothelin;

    Sammanfattning : Despite great efforts to reduce morbidity and mortality in ischaemic heart disease, this is still the most common cause of death in the industrialised countries. To improve the management of such patients, further knowledge is needed of the pathophysiology of ischaemic heart disease. LÄS MER

  3. 22. Markers of tissue ischaemia in lower limb arterial insufficiency : an experimental and clinical study

    Författare :Göran Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Limb ischaemia; diagnosis; metabolism; skeletal muscle; subcutaneous adipose tissue; microdialysis; muscle biopsy; lactate; perfusion; lower body positive pressure; human; rat; ;

    Sammanfattning : Lower limb ischaemic rest pain, ulcers or gangrene are late consequences of advanced peripheral arterial disease, one of the facets of systemic atherosclerosis. The majority of patients will meet current criteria for critical limb ischaemia (CLI). Life expectancy in these patients is severely limited mainly due to coexisting coronary heart disease. LÄS MER

  4. 23. The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide

    Författare :Adrian T Gonon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ischaemia; reperfusion injury; myocardium; infarct size; endothelium; endothelin; endothelin receptor; nitric oxide; nitric oxide synthase; polymorphonuclear leukocytes; myeloperoxidase; pig; rat;

    Sammanfattning : Acute myocardial infarction followed by reperfusion results in accelerated necrosis of irreversibly injured myocytes as well as induction of lethal injury to reversibly injured cells. Polymorphonuclear leukocytes (PMNs) are major participants in the reperfusion-initiated inflammation. LÄS MER

  5. 24. Monitoring and prevention of ischaemia-reperfusion injury in liver transplantation : experimental and clinical studies

    Författare :Grzegorz Nowak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Liver function after transplantation is determined not only by the quality of the donor organ or recipient related factors, but also by factors associated with organ preservation. During preservation, the liver graft is exposed to ischaemia and reperfusion with subsequent injury to the transplanted liver. LÄS MER

  7. 25. Spinal cord oxygenation during thoracic aortic clamping in pigs

    Författare :Anders Hellberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Thoracoabdominal aortic replacement; spinal cord ischaemia; cerebrospinal; intrathecal monitoring; oxygen tension; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Despite a dramatic reduction in the mortality associated with thoracoabdominal aorticreplacement during the past 40 years, spinal cord ischaemia that results in paraplegia remainsa serious complication. Simple and reliable intraoperative monitoring techniques are neededto detect impending neurological deficit in time to prevent permanent damage. LÄS MER