Sökning: "Inactivation"

Visar resultat 6 - 10 av 357 avhandlingar innehållade ordet Inactivation.

  1. 6. Voltage sensor activation and modulation in ion channels

    Författare :Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

    Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. LÄS MER

  3. 7. Inactivation, Cell Injury and Growth of Microorganisms Exposed to Pulsed Electric Fields Using a Continuous Process

    Författare :Kristina Aronsson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Leuconostoc mesenteroides; PEF; Listeria innocua; cell injury; flow-through treatment chamber; membrane permeabilization; post-processing growth; microbial inactivation; pulsed electric fields; Escherichia coli; Saccharomyces cerevisiae;

    Sammanfattning : Pulsed electric fields (PEF) is a proven technology to inactivate microorganisms under non-thermal conditions. The PEF technology has a potential as a "quality friendly" alternative to traditional methods of food preservation. LÄS MER

  4. 8. Inactivation of pulmonary surfactant and its prevention

    Författare :Guido Stichtenoth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pulmonary surfactant is a lipoprotein complex coating the conducting airways down to the terminal airspaces. Its main function is to lower surface tension at the air liquid interface thus preventing alveolar collapse at end expiration. LÄS MER

  5. 9. Vitamin D metabolism in osteoblast-like cells : effects of drugs on inactivation by CYP24A1

    Författare :Ahmad Zayny; Maria Norlin; Kjell Wikvall; Håkan Melhus; Inger Johansson; Fredrik Jerneren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical Biochemistry; Farmaceutisk biokemi; Pharmaceutical Biochemistry; Farmaceutisk biokemi;

    Sammanfattning : Vitamin D is essential for bone function, and deficiency in active vitamin D hormone can lead to bone disorders. Long-term treatment with glucocorticoids and antiretroviral drugs used to treat HIV infection, results in osteoporosis and increased risk of fractures. Much remains unclear regarding the effects of these compounds in bone cells. LÄS MER

  7. 10. Physiological consequences of Elongator complex inactivation in Eukaryotes

    Författare :Tony Karlsborn; Anders Byström; Hans Ronne; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Elongator complex; wobble uridine modifications; IKBKAP; IKAP; Familial dysautonomia; Untargeted Metabolic profiling.; molekylärbiologi; Molecular Biology;

    Sammanfattning : Mutations found in genes encoding human Elongator complex subunits have been linked to neurodevelopmental disorders such as familial dysautonomia (FD), rolandic epilepsy and amyotrophic lateral sclerosis. In addition, loss-of-function mutations in genes encoding Elongator complex subunits cause defects in neurodevelopment and reduced neuronal function in both mice and nematodes. LÄS MER