Sökning: "Kv1.2-2.1"

Hittade 2 avhandlingar innehållade ordet Kv1.2-2.1.

1. 1. Dynamics of the voltage-sensor domain in voltage-gated ion channels : Studies on helical content and hydrophobic barriers within voltage-sensor domains

   Författare :Christine S. Schwaiger; Erik Lindahl; Lynn Kamerlin; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage-sensor; VSD; Kv1.2- 2.1; F233; hydrophobic barrier; alpha-helix; 3 10 -helix; Biological physics; Biologisk fysik;

   Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability and thus dysfunctional channels can cause disease. Understanding how the voltage-sensor of these channels activate and inactivate could potentially be useful in future drug design of compounds targeting neuronal excitability. LÄS MER

3. 2. Voltage sensor activation and modulation in ion channels

   Författare :Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

   Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. LÄS MER