Sökning: "IGF binding proteins IGFBP"

Visar resultat 11 - 15 av 28 avhandlingar innehållade orden IGF binding proteins IGFBP.

1. 11. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

   Författare :Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Insulin-like growth factor;

   Sammanfattning : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. LÄS MER

3. 12. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

   Författare :Steven Gray; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

   Sammanfattning : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. LÄS MER

4. 13. The GH/IGF-1 system during surgery and catabolism : focus on metabolism and heart function

   Författare :Mats Wallin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : GH plays a role in both anabolism and catabolism. The anabolic properties of GH are mediated by circulating (endocrine) and locally secreted (paracrine) IGF-1. It is thus the IGF-1 response after increased GH secretion that determines whether metabolism will be anabolic or catabolic. LÄS MER

5. 14. New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination

   Författare :Maria A I Åberg; Göteborgs universitet; []
   Nyckelord :Brain; hippocampus; rat; neurogenesis; progenitor cell; stem cell; ciliary neurotrophic factor; insulin-like growth factor-I; PI3-K; MAPK.;

   Sammanfattning : The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. Two major events of significance for cell genesis from progenitor cells are proliferation and lineage determination. LÄS MER

7. 15. Molecular studies of the insulin-like growth factor system in the brain : focus on growth, tumorigenesis and trauma

   Författare :Ann-Christin Sandberg Nordqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :insulin-like growth factors; insulin-like growth factor binding proteins; brain; mRNA; meningioma; glioma; traumatic brain injury; in situ hybridization; Northern blothybridization;

   Sammanfattning : Insulin-like growth factor (IGF) 1 and -2 are synthesized by most tissues of the body and function as autocrine or paracrine agents in a tissue-specific manner. mRNA for IGF-1 and -2, as well as the IGF-binding proteins, are synthesized locally in various regions of the brain. LÄS MER