Sökning: "Spectral karyotyping"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Spectral karyotyping.
1. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma and other cartilage tumors
Sammanfattning : .... LÄS MER
2. Molecular studies of acute myeloid leukemia and the telomerase reverse transcriptase gene
Sammanfattning : Multiple chromosome rearrangements (MCRs) are detected in approximately 10% of patients with acute myeloid leukemia (AML), and are associated with an adverse prognosis. Comprehensive analysis of the chromosome rearrangements in these complex karyotypes has previously been hampered by the limitations of conventional cytogenetic techniques such as G-banding. LÄS MER
3. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors
Sammanfattning : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. LÄS MER
4. Cryptic chromosome abnormalities in idiopathic mental retardation
Sammanfattning : Mental retardation is a common disorder, affecting 1-3% of the population. In spite of improved diagnostic tools, the etiology can still not be established in half of the cases. Several lines of evidence indicate a genetic origin in a significant number of individuals with idiopathic mental retardation. LÄS MER
5. Characterisation of chromosomal aberrations in childhood leukaemia
Sammanfattning : Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood, accounting for approximately 25% of all paediatric malignancies. Based on clinical risk criteria and modem laboratory investigations including immunophenotyping, cytogenetics, and molecular genetics, patients can be divided into prognostic groups and assigned to risk- adjusted treatment protocols. LÄS MER