Sökning: "Spectral karyotyping"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Spectral karyotyping.

  1. 1. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma and other cartilage tumors

    Detta är en avhandling från Göteborg

    Författare :Helene Sjögren; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extraskeletal myxoid chondrosarcoma; chondroblastoma; chondrosarcoma; spectral karyotyping SKY ; chromosome translocation; fusion oncogene; cDNA microarray; TEC; EWS; TAF2N; TCF12;

    Sammanfattning : .... LÄS MER

  2. 2. Molecular studies of acute myeloid leukemia and the telomerase reverse transcriptase gene

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Molecular Medicine

    Författare :Charlotta Lindvall; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aacute myeloid leukaemia; telomerase hTERT; cancer cytogenetics; spectral karyotyping; gene expression profiling;

    Sammanfattning : Multiple chromosome rearrangements (MCRs) are detected in approximately 10% of patients with acute myeloid leukemia (AML), and are associated with an adverse prognosis. Comprehensive analysis of the chromosome rearrangements in these complex karyotypes has previously been hampered by the limitations of conventional cytogenetic techniques such as G-banding. LÄS MER

  3. 3. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Steven Gray; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

    Sammanfattning : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. LÄS MER

  4. 4. Cryptic chromosome abnormalities in idiopathic mental retardation

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Molecular Medicine

    Författare :Britt-Marie Anderlid; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mental retardation is a common disorder, affecting 1-3% of the population. In spite of improved diagnostic tools, the etiology can still not be established in half of the cases. Several lines of evidence indicate a genetic origin in a significant number of individuals with idiopathic mental retardation. LÄS MER

  5. 5. Characterisation of chromosomal aberrations in childhood leukaemia

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Molecular Medicine

    Författare :Ann Nordgren; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromosome aberrations; SKY; interphase-FISH; Childhood ALL;

    Sammanfattning : Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood, accounting for approximately 25% of all paediatric malignancies. Based on clinical risk criteria and modem laboratory investigations including immunophenotyping, cytogenetics, and molecular genetics, patients can be divided into prognostic groups and assigned to risk- adjusted treatment protocols. LÄS MER