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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.
1. Interferons in immunity to chlamydia pneumoniae
Sammanfattning : The cytokine IFN-gamma is the architect behind an amazing immunological program of host resistance to intracellular bacterial and protozoan infections. IFN-gamma activates macrophages, making them into inhospitable habitats for parasites attempting to grow inside them. LÄS MER
2. Studies of the recognition and activation of natural killer cells
Sammanfattning : Natural killer (NK) cells mediate part of the innate immune response that impedes the spread of invading microorganisms and shapes the downstream adaptive immune response. NK cells spontaneously kill tumor cells and other cells upon contact. Killing requires engagement of germline encoded receptors that mediate positive and negative signals. LÄS MER
3. Experimental Chagas disease
Sammanfattning : The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection and what factors that predispose to a chronic inflammatory disease after T. cruzi infection. LÄS MER
4. Host control of intracellular bacterial infections
Sammanfattning : In this thesis various immune mechanisms regulating control of infections with the intracellular bacteria Listeria monocytogenes and Chlamydia pneumoniae have been studied. These bacteria infect macrophages in which they can successfully grow. However, macrophages are potent killers of intracellular bacteria. LÄS MER
5. Immune regulation of herpes simplex virus type 2 infection: Special emphasis on the transcription factor T-bet
Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa as well as local sensory neurons. It is the most common cause of genital ulcer disease in humans. The infection gives rise to a wide range of symptoms, ranging from severe and painful recurrent episodes of genital herpes to silent infection. LÄS MER