Sökning: "IFNalpha beta"

Hittade 5 avhandlingar innehållade orden IFNalpha beta.

  1. 1. Arthritogenecity of RNA and its degradation products

    Författare :Fariba Zare; Göteborgs universitet; []
    Nyckelord :dsRNA; ssRNA; virus; arthritis; TLR3; IL-1R; IFNalpha beta receptor; plasminogen; tissue factor; uric acid; inflammation; arthritis; neutrophils;

    Sammanfattning : Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to induce production of pro-inflammatory cytokines, e.g., interferon-alpha (IFN-alpha). LÄS MER

  3. 2. Host control of intracellular bacterial infections

    Författare :Emma Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Listeria monocytogenes; CD44; flagellin; Chlamydia pneumoniae; TLR; NOD; IFNalpha beta; IFN-gamma;

    Sammanfattning : In this thesis various immune mechanisms regulating control of infections with the intracellular bacteria Listeria monocytogenes and Chlamydia pneumoniae have been studied. These bacteria infect macrophages in which they can successfully grow. However, macrophages are potent killers of intracellular bacteria. LÄS MER

  4. 3. Interferons in immunity to chlamydia pneumoniae

    Författare :Antonio Carlos Gigliotti (Tony) Rothfuchs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chlamydia pneumoniae; TLR; IFN-alpha beta; IFN-gamma; macrophages; T cells;

    Sammanfattning : The cytokine IFN-gamma is the architect behind an amazing immunological program of host resistance to intracellular bacterial and protozoan infections. IFN-gamma activates macrophages, making them into inhospitable habitats for parasites attempting to grow inside them. LÄS MER

  5. 4. Coxsackie B virus pathogenesis in mice

    Författare :Maria Hindersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Coxsackie B virus (CVB) belongs to the enterovirus (EV) genera of the Picornaviridae family. These infections range from asymptomatic, mild infections to serious diseases such as myocarditis, pancreatitis, paralysis, aseptic meningitis and encephalitis. LÄS MER

  7. 5. The role of autoantibodies in inflammatory myopathies

    Författare :Sevim Barbasso Helmers; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Idiopathic inflammatory myopathies; polymyositis; dermatomyositis; inclusion body myositis; ILD; IVIG; IFN; BAFF; endothelial cells; anti-Jo-1;

    Sammanfattning : Polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM), collectively called myositis, are chronic inflammatory myopathies. These disease subsets are heterogeneous but share some features, such as skeletal muscle weakness and inflammatory cell infiltrates in muscle tissue. LÄS MER