Sökning: "Heterochromatin"
Visar resultat 16 - 20 av 44 avhandlingar innehållade ordet Heterochromatin.
16. DNA G-quadruplex structures in the mammalian genome : dissecting genome-wide mechanisms of formation and turnover of DNA G-quadruplexes
Sammanfattning : Since the beginning of 20th century, when the G-tetrad was first discovered, scientists have been seeking to understand the role of G4 quadruplex structures (G4s) in replication, DNA damage, telomere integrity and the regulation of gene expression. However, it is likely that the field has just scratched the tip of the iceberg when it comes to assessing and interpreting the function of individual G4s, forming in a specific locus, in the complex context of chromatin. LÄS MER
17. The role of nuclear membrane proteins in differentiation and chromatin organization
Sammanfattning : The nuclear envelope, consisting of an outer and an inner nuclear membrane, surrounds the genomic material. The genomic material (chromatin) is highly structured with (transcriptionally inactive) heterochromatin mostly found in the nuclear periphery and (transcriptionally active) euchromatin mostly found in the nuclear interior. LÄS MER
18. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster
Sammanfattning : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. LÄS MER
19. Organization of centromere associated DNA in Chironomus pallidivittatus
Sammanfattning : Centromeres have not yet been functionally defined in higher eu- karyotes, largely due to the huge amounts of repeated DNA in these regions of most species and difficulties of delimiting centromeric from pericentric regions. Also the latter have large quantities of mostly noncoding DNA, expressed cytologically as pericentric heterochromatin. LÄS MER
20. Genome-wide patterns of histone modifications in fission yeast
Sammanfattning : DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to activate or suppress a particular gene or group of genes. Histones can be covalently modified at several places. LÄS MER
