Sökning: "Lina Lundberg"

Hittade 1 avhandling innehållade orden Lina Lundberg.

  1. 1. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster

    Författare :Lina Lundberg; Jan Larsson; Brian Oliver; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genome-wide gene regulation; aneuploidy; buffering; HP1a; POF; SETDB1; Su var 3-9; MSL; roX; genetik; Genetics;

    Sammanfattning : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. LÄS MER