Sökning: "Hepatobiliary transport"

Hittade 2 avhandlingar innehållade orden Hepatobiliary transport.

  1. 1. The Hepatobiliary Transport of Rosuvastatin In Vivo

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ebba Bergman; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; PHARMACY Biopharmacy; FARMACI Biofarmaci; Biopharmaceutics; biofarmaci;

    Sammanfattning : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. LÄS MER

  2. 2. In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Elin Matsson; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Direct thrombin inhibitors; prodrugs; ximelagatran; AZD0837; erythromycin; ketoconazole; drug-drug interactions; hepatobiliary transport; biliary clearance; ATP-binding cassette; ABC transporters; solute carriers; SLC transporters; CYP3A4; PHARMACY Biopharmacy; FARMACI Biofarmaci; Biopharmaceutics; Biofarmaci;

    Sammanfattning : Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. LÄS MER