Sökning: "Granulocyte-macrophage colony-stimulating factor GM-CSF"
Visar resultat 11 - 15 av 21 avhandlingar innehållade orden Granulocyte-macrophage colony-stimulating factor GM-CSF.
11. The Myc network of growth regulators and its interplay with growth and differentiation signals
Sammanfattning : The proto-oncogenes/tumor suppressor genes of the Myc/N4ax/Mad network encode transcription factors that are important regulators of cell growth, differentiation, and apoptosis and that are frequently implicated in tumor development. Regulation of their biological functions by growth/differentiation signals as well as their interplay with growth/differentiation signalling pathways play important roles in cell fate determination. LÄS MER
12. Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients
Sammanfattning : In spite of the promising results shown by new anti-myeloma agents, multiple myeloma (MM) remains incurable and additional therapy to overcome the inevitable disease recurrence is greatly needed. Immunotherapy is currently under evaluation as a novel alternative or complementary therapy in many cancer types. LÄS MER
13. Immunological and molecular studies for the development of vaccine therapy for chronic lymphocytic leukemia
Sammanfattning : Chronic lymphocytic leukaemia (CLL) is a malignant lymphoproliferative disorder which typically affects elderly people. It is the commonest leukemia in the Western adults, accounting for 25-30% of all leukemias and for 10% of all hematological neoplasms. LÄS MER
14. Matrix metalloproteases and cell motility in malignant mesothelioma
Sammanfattning : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. LÄS MER
15. Cancer vaccine strategies and studies of human thioredoxin reductase splice variants
Sammanfattning : Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I antigen machinery, e.g. the beta2-microglobulin (beta2m) molecule. LÄS MER