Sökning: "p21Cip1"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet p21Cip1.

  1. 1. The Myc network of growth regulators and its interplay with growth and differentiation signals

    Författare :Siqin Wu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; p21Cip1; phorbol ester; IFN-g; TGF-b; differentiation; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : The proto-oncogenes/tumor suppressor genes of the Myc/N4ax/Mad network encode transcription factors that are important regulators of cell growth, differentiation, and apoptosis and that are frequently implicated in tumor development. Regulation of their biological functions by growth/differentiation signals as well as their interplay with growth/differentiation signalling pathways play important roles in cell fate determination. LÄS MER

  3. 2. Role of integrin signaling in cell proliferation and survival

    Författare :Wenjie Bao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Integrins function as transmembrane cell adhesion receptors for the surrounding extracellular matrix (ECM). Within the tissues, integrins attach the cells to the surrounding ECM and sense the ECM environment by triggering diverse arrays of signaling pathways that are essential for the control of many central cellular functions, including cell proliferation and survival. LÄS MER

  4. 3. The oncogenic role of histone chaperone ASF1 proteins in solid tumors

    Författare :Yujiao Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chromatin is the essential medium connecting regulatory signals such as transcription factors and signaling pathways to the alteration of gene activity and cellular phenotypes. Aberrant chromatin (epigenetic) environment plays an important role in carcinogenesis. LÄS MER

  5. 4. Ras-MAPK signaling in differentiating SH-SY5Y human neuroblastoma cells

    Författare :Anna-Karin Olsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Neuroblastoma; SH-SY5Y; differentiation; neurite; Ras; MAPK; PKC; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Neuroblastoma is a malignant childhood cancer, originating from sympathetic neuroblasts of the peripheral nervous system. Neuroblastoma is a heterogenous group of tumours, while some are highly malignant others can spontaneosly mature into a more benign form or regress. LÄS MER

  7. 5. p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors

    Författare :Jonas Fuxe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The astrocytic gliomas are the most common form of brain tumors in humans. The malignant progression from low grade (astrocytoma, grade II) to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well documented and is accompanied by an increasing number of genetic aberrations. LÄS MER