Sökning: "Gene-gene effect"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Gene-gene effect.
1. On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism
Sammanfattning : Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. LÄS MER
2. Genetic dissection of multifactorial disease models in the rat
Sammanfattning : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. LÄS MER
3. Genes to remember : imaging genetics of hippocampus-based memory functions
Sammanfattning : In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In this thesis, three of the strongest candidate genes for episodic memory, KIBRA, BDNF, and APOE, were examined in relation to memory performance and hippocampal/parahippocampal fMRI blood-oxygen level-dependent (BOLD) signal. LÄS MER
4. Heredity in Parkinson's disease. From rare mutations to common genetic risk factors
Sammanfattning : This study investigated genetic causes of Parkinson's disease (PD) and parkinsonism in southern Sweden. The extensive Lister Family with parkinsonism caused by duplications and triplications of the gene for alpha-synuclein (SNCA) was studied. Clinical, genetic and genealogical data were compiled and evaluated. LÄS MER
5. Genetic regulation of autoimmune neuroinflammation
Sammanfattning : Multiple sclerosis (MS) is a complex disease characterized by inflammation and demyelination in the central nervous system (CNS), causing neurological deficits. Although there is an increased familial aggregation rate and evidence for a genetic influence on disease susceptibility, environmental factors are also of importance. LÄS MER