Sökning: "TPH2"
Hittade 5 avhandlingar innehållade ordet TPH2.
1. On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism
Sammanfattning : Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. LÄS MER
2. Mind really does matter : The Neurobiology of Placebo-induced Anxiety Relief in Social Anxiety Disorder
Sammanfattning : The placebo effect, a beneficial effect attributable to a treatment containing no specific properties for the condition being treated, has been demonstrated in a variety of medical conditions. This thesis includes four studies aimed at increasing our knowledge on the neurobiology of placebo. LÄS MER
3. Experimental, mild blast-induced traumatic brain injury : focus on the monoamine and galanin systems
Sammanfattning : Traumatic brain injury (TBI) is a common cause of mortality and morbidity among civilians and servicemen alike. The spectrum of TBIs encompasses mild to severe cases, with the predominate number of TBIs being mild (mTBI). Combat-related TBI inflicted by explosive blast (bTBI) is highly prevalent among military personnel. LÄS MER
4. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
Sammanfattning : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). LÄS MER
5. Neuropeptides in the human postmortem brain : focus on galanin and its receptors in depression
Sammanfattning : Neuropeptides represent the most diverse family of messenger molecules in the nervous system, which are co-expressed with key neurotransmitters in several brain regions. They modulate synaptic neurotransmission and have, in some cases, also trophic functions. One such neuropeptide, and the focus of the thesis, is ‘galanin’. LÄS MER