Sökning: "MDR mRNA"

Hittade 5 avhandlingar innehållade orden MDR mRNA.

1. 1. Aspects on puberty and fertility among females with cystic fibrosis a multidisciplinary study on humans and rats

   Författare :Marie Johannesson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cystic fibrosis; puberty; fertility; hormonal profiles; CFTR mRNA; MDR mRNA; rat brain; pregnant rat lung; psychosocial aspects.;

   Sammanfattning : Due to intensified symptomatic treatment, a majority of patients with cystic fibrosis (CF) now go through puberty and reach adulthood. This provides new challenges for the CF health care providers. LÄS MER

3. 2. Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines

   Författare :Kerstin Jönsson Videsäter; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Multidrug resistance; cross-resistance profile; ATP-bioluminescence assay; pglycoprotein; MRP1; selenium; thioredoxin reductase; glutathione reductase.;

   Sammanfattning : Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of multidrug resistance and to establish in vitro methods to characterize the resistant tumor cell phenotype. LÄS MER

4. 3. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

   Författare :Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
   Nyckelord :Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

   Sammanfattning : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. LÄS MER

5. 4. Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human

   Författare :Hanjing Xie; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cyclophosphamide; Cytochrome P450; Metabolism; Pharmacokinetics; 4Hydroxycyclophosphamide;

   Sammanfattning : Cyclophosphamide (CPA) is widely used anti-cancer drug that has to be catalyzed by the cytochrome P450 (CYP) enzyme 2B6 as well as some other CYPs to exert its cytotoxic activity. A high degree of interindividual variation in CPA kinetics has been reported in both children and adult patients, which may be due to several factors such as concomitantly used drugs, variation in physiological status of individual patients and genetic polymorphism of the CYP enzymes. LÄS MER

7. 5. Pharmacological and clinical studies of new ways to improve cytostatic treatment of acute myelocytic leukemia : in vitro and in vivo studies

   Författare :Christina Löfgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Treatment failure in refractory or relapsed disease is often caused by resistance towards Ara-C or daunorubicin, the two drugs mainly used in the treatment of acute myeloid leukemia (AML). This thesis comprises studies of resistance mechanisms regarding Ara-C and the newer nucleoside analogues CdA and fludarabine, improvement of treatment outcome after enhancement of tumour AraC susceptibility by concomitant treatment with GM-CSF and the effect of liposomal formulation on leukemic cell uptake of daunorubicin. LÄS MER