Sökning: "Françoise Raffalli-Mathieu"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Françoise Raffalli-Mathieu.

  1. 1. Regulation of Adenoviral Gene Expression by the L4-33K and L4-22K Proteins

    Författare :Ellenor Backström; Göran Akusjärvi; Francoise Raffalli-Mathieu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Virologi; Medical Virology; Medicinsk virologi;

    Sammanfattning : The splicing pattern during an adenovirus infection is shifted at the late phase towards using weaker splice sites, splicing out larger introns. Splicing of weak 3´ splice sites usually requires recognition of the 3´AG dinucleotide before the first catalytic step of splicing. LÄS MER

  3. 2. The role of hnRNP A1 and hnRNP C1/C2 in the regulation of the stress responsive genes Cyp2a5/2A6 and p53

    Författare :Kyle Christian; Matti Lang; Françoise Raffalli-Mathieu; Kirsi Vähägangas; Uppsala universitet; []
    Nyckelord :Molecular biology; hnRNP; Tumor Suppressor Protein p53; CYP2A5; CYP2A6; Apoptosis; hnRNP C Proteins; hnRNP protein A1; Cancer; Molekylärbiologi;

    Sammanfattning : The family of proteins known as heterogeneous nuclear ribonucleoproteins (hnRNPs) is large and diverse. Often, one and the same hnRNP will perform multiple cellular functions, leading to their description as “multifunctional proteins”. LÄS MER

  4. 3. Alpha-class Glutathione Transferases from Pig: a Comparative Study

    Författare :Natalia Fedulova; Bengt Mannervik; Francoise Raffalli-Mathieu; Mario Lo Bello; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glutathione transferase; substrate selectivity; steroidogenesis; Sus scrofa; functional comparison; irreproducibility; reproducible assays; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : Glutathione transferases (GSTs, EC 2.5.1.18) possess multiple functions and have potential applications in biotechnology. LÄS MER

  5. 4. The Multifunctional HnRNP A1 Protein in the Regulation of the Cyp2a5 Gene : Connecting Transcriptional and Posttranscriptional Processes

    Författare :Tina Glisovic; Matti Lang; Francoise Raffalli-Mathieu; Lorenz Poellinger; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; Cyp2a5; DNA-protein interaction; gene regulation; hnRNP A1; nucleocytoplasmic shuttling; RNA-protein interaction; RNA stabilization; posttranscriptional; transcriptional; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Sammanfattning : The mouse xenobiotic-inducible Cyp2a5 gene is both transcriptionally and posttranscriptionally regulated. One of the most potent Cyp2a5 inducers, the hepatotoxin pyrazole, increases the CYP2A5 mRNA half-life. LÄS MER

  7. 5. Design of Glutathione Transferase Variants for Novel Activities with Alternative Substrates

    Författare :Abeer Shokeer; Bengt Mannervik; Francoise Raffalli-Mathieu; David Josephy; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Organic chemistry; Organisk kemi; Biokemi; Biochemistry; Organisk kemi; Organic Chemistry;

    Sammanfattning : Glutathione transferases (GSTs) play a pivotal role in cellular defense, since they are main contributors to the inactivation of genotoxic compounds of exogenous and endogenous origins. Directed evolution was used to improve the catalytic activities of Theta class GST T1-1 toward different substrates. LÄS MER