Sökning: "reproducible assays"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden reproducible assays.
1. Alpha-class Glutathione Transferases from Pig: a Comparative Study
Sammanfattning : Glutathione transferases (GSTs, EC 2.5.1.18) possess multiple functions and have potential applications in biotechnology. LÄS MER
2. Development and biomedical applications of highly sensitive enzyme activity assays of thioredoxin, thioredoxin reductase and glutaredoxin
Sammanfattning : Oxidative stress is implicated in the pathogenesis of many human diseases, thus it is interesting to study the relationship between antioxidants, the development and progression of diseases. The thioredoxin and glutaredoxin systems are ubiquitous redox-active proteins known to be induced in chronic inflammatory related processes, such as cancer and diabetes, to protect against oxidative stress. LÄS MER
3. Amino acid sequence and side chain specific synthetic receptors targeting protein phosphorylation
Sammanfattning : Antibodies have become a critical component of many diagnostic assays and are used for therapeutic purposes. Nevertheless they often fail to meet the strict performance demands raised in industry and in the clinic (e.g. stability, reproducibility, selectivity, affinity). LÄS MER
4. Integrating extrinsic and intrinsic cues to guide cell fate decisions : rational approaches in stem cell engineering
Sammanfattning : The long-term goal of stem cell engineering is to generate functional cells for cell replacement therapies, disease modelling and in drug development assays. It is evident that one of the major challenges in stem cell research is to develop reproducible methods to obtain well-defined and pure populations of clinically relevant cell types in a sustainable manner. LÄS MER
5. Studies on methotrexate and cladribine : bioanalytical, pharmacokinetic, and clinical aspects
Sammanfattning : The aim of these studies was to delineate the pharmacokinetics of methotrexate (MTX) and cladribine in order to improve the basis for individualization and optimization of treatment with these two antimetabolites. Methodological aspects of MTX assays in clinical routine usage were investigated as plasma MTX determinations are mandatory in the high-dose treatment of childhood acute Iymphoblastic leukemia (ALL). LÄS MER