Sökning: "Tumor Suppressor Protein p53"

Visar resultat 1 - 5 av 77 avhandlingar innehållade orden Tumor Suppressor Protein p53.

1. 1. On the Role of the Tumor Suppressor p53 in Leukemic Cell Differentiation

   Författare :Mats Ehinger; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; p53; Tumor Suppressor Genes; Leukemia; Differentiation; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. LÄS MER

3. 2. On the role of the retinoblastoma tumor suppressor gene in hematopoietic differentiation

   Författare :Gösta Bergh; Helsingborg Kliniska Vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antisense; leukemia; cell cycle; differentiation; hematopoiesis; p16; p53; tumor suppressor genes; RB; oligonucleotides; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : The aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. LÄS MER

4. 3. TRIM22/Staf50 - a novel target gene of the tumor suppressor p53

   Författare :Susanna Obad; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; Medicin människa och djur ; Medicine human and vertebrates ; T lymphocyte; apoptosis; PML; differentiation; hematopoiesis; leukemia; interferon; p53; TRIM22 Staf50; extracellulära vätskor;

   Sammanfattning : The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. LÄS MER

5. 4. Pathophysiological impact of targeting the ROS-p53 axis

   Författare :Volkan I. Sayin; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antioxidants; Cancer; p53; ROS; atherosclerosis;

   Sammanfattning : The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. LÄS MER

7. 5. The role of hnRNP A1 and hnRNP C1/C2 in the regulation of the stress responsive genes Cyp2a5/2A6 and p53

   Författare :Kyle Christian; Matti Lang; Françoise Raffalli-Mathieu; Kirsi Vähägangas; Uppsala universitet; []
   Nyckelord :Molecular biology; hnRNP; Tumor Suppressor Protein p53; CYP2A5; CYP2A6; Apoptosis; hnRNP C Proteins; hnRNP protein A1; Cancer; Molekylärbiologi;

   Sammanfattning : The family of proteins known as heterogeneous nuclear ribonucleoproteins (hnRNPs) is large and diverse. Often, one and the same hnRNP will perform multiple cellular functions, leading to their description as “multifunctional proteins”. LÄS MER