Sökning: "Flt3-ITD"
Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet Flt3-ITD.
6. Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities
Sammanfattning : Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. LÄS MER
7. Prognostic markers in acute myeloid leukemia : A candidate gene approach
Sammanfattning : The standard treatment of acute myeloid leukemia (AML) consists of induction chemotherapy, most commonly daunorubicin together with the nucleoside analogue cytarabine (Ara-C), followed by consolidation chemotherapy and in selected cases allogenic stem cell transplantation (allo-SCT). Despite a high initial response rate, a considerable proportion of all AML cases eventually suffer from relapse and the five-year overall survival rate in patients >60 years is only around 15%. LÄS MER
8. The FLT3 Tyrosine Kinase in Leukemia : Deciphering the Downstream Signaling Events and Drug-Escape Mechanisms
Sammanfattning : Acute myeloid leukemia (AML) is a severe disease, which originates in blood-forming cells. Although major advances in understanding the biology of AML, the majority of patients eventually succumb to the disease. LÄS MER
9. Strategies to overcome drug resistance in FLT3+ AML
Sammanfattning : Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor survivalrate and limited therapeutic options. Targeted treatment of other types ofcancer, for instance chronic myeloid leukemia (CML) and breast cancer, has seensignificant progress. LÄS MER
10. Translational studies on acute myeloid leukemia focus on the receptor tyrosine kinase FLT3
Sammanfattning : Among adults, acute myeloid leukemia (AML) is the second most frequent type of leukemia. In spite of recent improvements in the treatment of this disease, a majority of patients develop drug resistance, leading to poor overall survival. One of the factors behind this is mutations in the tyrosine kinase receptor (FLT3). LÄS MER