Sökning: "FPRL1"

Hittade 5 avhandlingar innehållade ordet FPRL1.

  1. 1. Recognition by leukocyte formyl peptide receptors. Promiscuous binding or pattern recognition?

    Författare :Johan Bylund; Göteborgs universitet; []
    Nyckelord :neutrophils; chemoattractant; FPRL1; NADPH-oxidase; LPS; priming; subcellular organelles; human; murine;

    Sammanfattning : Neutrophil granulocytes play an important role in the early stages of microbial infection. The neutrophils have to leave the blood stream and migrate out into the tissue where they phagocytose microbes and cell debris from damaged host tissues. LÄS MER

  3. 2. Functional dualism of antimicrobial host defence peptides

    Författare :Åse Björstad; Göteborgs universitet; []
    Nyckelord :antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

    Sammanfattning : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. LÄS MER

  4. 3. Granulocyte activation by danger signals and blocking of receptor responses

    Författare :Anna-Lena Stenfeldt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; granulocytes; neutrophils; eosinophils; danger signals; danger theory; formyl peptide receptors; antagonists; inhibitors;

    Sammanfattning : Granulocytes are the most abundant cells in the peripherial blood. They serve to eliminate invading microbes and parasites and release anti-microbial agents. In the event of injury, granulocytes are recruited to damaged tissues. LÄS MER

  5. 4. Chemoattractant receptor signaling and neutrophil acctivation. Involvement of the cytoskeleton

    Författare :Huamei Fu; Göteborgs universitet; []
    Nyckelord :neutrophils; G-protein coupled receptors; signaling; cytoskeleton;

    Sammanfattning : Neutrophil granulocytes play a vital role in the host surveillance system and form the first line of defense against microbial infections. The migration of neutrophils to an infected/inflamed tissue is guided by chemoattractants released either from intruding microbes or from activated/damaged host cells. LÄS MER

  7. 5. Reactive oxygen species as signalling molecules in immunity

    Författare :Åsa Betten; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reactive oxygen species; NK cells; phagocytes; serotonin; histamine; myeloperoxidase;

    Sammanfattning : Cytotoxic lymphocytes such as natural killer (NK) cells and subsets of T cells are key components of the host defense against malignancy and infection. Earlier studies have demonstrated that NK cells and several phenotypes of T cells become dysfunctional and apoptotic after exposure to autologous monocyte/macrophages and other phagocytes. LÄS MER