Sökning: "host defence peptide"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden host defence peptide.

  1. 1. Functional dualism of antimicrobial host defence peptides

    Författare :Åse Björstad; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

    Sammanfattning : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. LÄS MER

  2. 2. Midkine - a host defence protein

    Författare :Sara Nordin; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antimicrobial polypeptides; Midkine; antibacterial; antifungal; innate immunity; epithelial surfaces;

    Sammanfattning : Every day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad range of microbes rapidly. LÄS MER

  3. 3. On airway host defence during allergic inflammation

    Författare :Anele Gela; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :Asthma; COPD; Antimicrobial peptide; chemokines; immunology;

    Sammanfattning : Asthma is a chronic inflammatory disease of the airways, affecting and disablingapproximately 300 million people worldwide. The inflammatory profile ischaracterized by infiltration of eosinophils, which are a rich source of factors thatare implicated in tissue remodeling. LÄS MER

  4. 4. Novel Aspects of the Coagulation System in Host Defence

    Författare :Praveen Papareddy; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host defence peptides; Coagulation system; Sepsis; Thrombin; TFPI-1; TFPI-2; HCII;

    Sammanfattning : Bacterial infections are a major global threat to public health and sepsis is a major cause of morbidity and mortality. Sepsis incidence is rising, with supportive treatments and antibiotics being the main treatment possibilities. LÄS MER

  5. 5. Regulation of human cell viability by the host defence peptide LL-37

    Författare :Daniel Svensson; Kärlfysiologi; []
    Nyckelord :LL-37; cathelicidin; cytotoxicity; host defence peptides; autoimmune diseases; inflammation; vitamin D;

    Sammanfattning : Accumulating evidence suggests that the main human cathelicidin peptide, LL-37, may influence host cell viability and pro-inflammatory signaling when locally overexpressed. LL-37 has pro-inflammatory properties linked to the development of for example psoriasis, rosacea, SLE and atherosclerosis. LÄS MER